4-Bromo-2-[(morpholin-4-yl)methyl]phenol

Base Information

• Chemical Name: 4-Bromo-2-[(morpholin-4-yl)methyl]phenol
• CAS No.: 60460-70-0
• Molecular Formula: C₁₁H₁₄BrNO₂
• Molecular Weight: 272.142
• European Community (EC) Number: 856-032-8
• Nikkaji Number: J1.737.196G
• Mol file: 60460-70-0.mol

Synonyms:AKOS020287519;60460-70-0;4-bromo-2-[(morpholin-4-yl)methyl]phenol;EN300-9578344

Chemical Property of 4-Bromo-2-[(morpholin-4-yl)methyl]phenol

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 271.02079
• Heavy Atom Count: 15
• Complexity: 197

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1COCCN1CC2=C(C=CC(=C2)Br)O

Technology Process of 4-Bromo-2-[(morpholin-4-yl)methyl]phenol

There total 4 articles about 4-Bromo-2-[(morpholin-4-yl)methyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

potassium (morpholin-4-yl)methyltrifluoroborate + 4-bromo-phenol (106-41-2) → 4-bromo-2-(N-morpholinyl)methylphenol (60460-70-0) + 2,6-bis-(N-methylenemorpholino)-4-bromophenol (156215-24-6)

Guidance literature:

With copper diacetate; sodium acetate; In toluene; at 80 ℃; for 18h;

DOI:10.1021/jacs.7b06785

Reference yield: 69.0%

morpholine (110-91-8,99108-56-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-Bromophenylboronic acid (5467-74-3) → 4-bromo-2-(N-morpholinyl)methylphenol (60460-70-0)

Guidance literature:

With tert.-butylhydroperoxide; In water; toluene; at 80 ℃; for 8h; Solvent; regioselective reaction; Sealed tube;

DOI:10.1016/j.tetlet.2017.02.081

Reference yield: 33.0%

4-bromo-phenol (106-41-2) + 4-methylmorpholine N-oxide (7529-22-8) → 4-bromo-2-(N-morpholinyl)methylphenol (60460-70-0)

Guidance literature:

bis(acetylacetonate)oxovanadium; In dichloromethane; for 48h; Heating;

DOI:10.1021/ol017229j

upstream raw materials:

4-bromo-phenol

4-methylmorpholine N-oxide

morpholine

formaldehyd

Downstream raw materials:

N-(5-bromo-2-methoxybenzyl)morpholine