(R)-ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate

Base Information

Chemical Name:(R)-ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate
CAS No.:611227-63-5
Molecular Formula:CH₄O₃S*C₁₃H₁₇NO₃
Molecular Weight:331.39
Hs Code.:

Synonyms:(R)-ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate

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Chemical Property of (R)-ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate

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Technology Process of (R)-ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate

There total 4 articles about (R)-ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 611227-60-2
ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate

: 75-75-2,98527-29-8
methanesulfonic acid

: 611227-63-5
(R)-ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate

Guidance literature:: ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate; With sodium hydroxide; 2-amino-2-hydroxymethyl-1,3-propanediol; In water; at 38 ℃; for 2.5h; Resolution of racemate; Large scale reaction;

methanesulfonic acid; In ethyl acetate; isopropyl alcohol; at 10 ℃; for 1h; optical yield given as %ee; Large scale reaction;
DOI:10.1021/op800308t

Reference yield: 42.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 611227-63-5
(R)-ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate

Guidance literature:: With sodium hydroxide; 2-amino-2-hydroxymethyl-1,3-propanediol; In water; at 40 ℃; for 5h; pH=6.8 - 8.3;

methanesulfonic acid; In water; ethyl acetate; isopropyl alcohol; at 10 - 55 ℃; for 4.66667h; Purification / work up;

Reference yield:

: 611227-57-7
C₁₈H₁₉NO₃

: 106-95-6
allyl bromide

: 611227-63-5
(R)-ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate

Guidance literature:: C₁₈H₁₉NO₃; allyl bromide; With lithium tert-butoxide; In tetrahydrofuran; at -5 - 5 ℃; for 1.5h;

With sodium hydroxide; water; In ethyl acetate; pH=8 - 9;

With methanesulfonic acid; In ethyl acetate; isopropyl alcohol; at 0 - 60 ℃; for 3h; Heating / reflux;