(S)-2-(1-chloro-2-phenylethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

Chemical Name:(S)-2-(1-chloro-2-phenylethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS No.:1259299-92-7
Molecular Formula:C₁₄H₂₀BClO₂
Molecular Weight:266.576
Hs Code.:

Synonyms:(S)-2-(1-chloro-2-phenylethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(1-chloro-2-phenylethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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Technology Process of (S)-2-(1-chloro-2-phenylethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 13 articles about (S)-2-(1-chloro-2-phenylethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1259299-79-0
2-(1-chloro-2-phenylvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1259299-92-7
(S)-2-(1-chloro-2-phenylethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 165904-22-3
4,4,5,5-tetramethyl-2-phenethyl-1,3,2-dioxaborolane

Guidance literature:: With (η-1,5-cyclooctadiene) {[4(R),5(R)]-1-benzoyl-2-[(S)-2-diphenylphosphinoferrocenyl]-4,5-diphenyl-4,5-dihydro-1-imidazole} iridium(I) tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; hydrogen; In dichloromethane; at 50 ℃; for 12h; under 7500.75 Torr; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/anie.201106262

Reference yield:

: 75-09-2
dichloromethane

: 87100-28-5
pinacol benzylboronate

: 1259299-92-7
(S)-2-(1-chloro-2-phenylethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: dichloromethane; pinacol benzylboronate; With lithium diisopropyl amide; In diethyl ether; at -78 ℃; for 0.25h;

With C₃₄H₄₂BClF₆N₃O₃S^(1-)*Li⁽¹⁺⁾; In diethyl ether; at -35 ℃; for 20h; enantioselective reaction;
DOI:10.1126/science.abm0386

Reference yield:

: 1259299-79-0
2-(1-chloro-2-phenylvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1259299-92-7
(S)-2-(1-chloro-2-phenylethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1259299-91-6
(R)-2-(1-chloro-2-phenylethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: With (η-1,5-cyclooctadiene) {[4(R),5(R)]-1-benzoyl-2-[(S)-2-diphenylphosphinoferrocenyl]-4,5-diphenyl-4,5-dihydro-1-imidazole} iridium(I) tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; hydrogen; In dichloromethane; at 50 ℃; for 12h; under 7500.75 Torr; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/anie.201106262