O-(4-Hydroxy-3,5-di(125I)iodophenyl)-3,5-di(125I)iodo-L-tyrosine

Base Information

• Chemical Name: O-(4-Hydroxy-3,5-di(125I)iodophenyl)-3,5-di(125I)iodo-L-tyrosine
• CAS No.: 24486-40-6
• Molecular Formula: C₁₅H₁₁I₄NO₄
• Molecular Weight: 776.875
• Mol file: 24486-40-6.mol

Synonyms:Thyroxine,labeled with iodine-125, L- (8CI); L-Thyroxine labeled with iodine-125;Thyroxine labeled with iodine-125; Thyroxine-125I

Chemical Property of O-(4-Hydroxy-3,5-di(125I)iodophenyl)-3,5-di(125I)iodo-L-tyrosine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

THYROXINE I 125 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Tetramet (Abbott).

Technology Process of O-(4-Hydroxy-3,5-di(125I)iodophenyl)-3,5-di(125I)iodo-L-tyrosine

There total 52 articles about O-(4-Hydroxy-3,5-di(125I)iodophenyl)-3,5-di(125I)iodo-L-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

L-thyroxine, sodium salt hexahydrate → L-thyroxine (51-48-9,24486-40-6)

Guidance literature:

With hydrogenchloride; In methanol; dimethyl sulfoxide;

Reference yield: 94.0%

3,5-diiodo-l-tyrosine (300-39-0) + 5,7-diiodo-1-oxaspiro[2.5]octa-4,7-dien-6-one → L-thyroxine (51-48-9,24486-40-6)

Guidance literature:

In N,N-dimethyl-formamide; at 24 ℃; for 16h; 0.2 M borate buffer, pH 8.0 (add. of 0.1 M NaOH);

DOI:10.1016/S0040-4039(97)01665-1

Reference yield: 91.2%

3,3′-diiodothyronine (70-40-6) → L-thyroxine (51-48-9,24486-40-6)

Guidance literature:

3,3′-diiodothyronine; With methylamine; In methanol; at 25 - 30 ℃;

With iodine; In methanol; at -8 - 0 ℃;

With potassium dihydrogenphosphate; sodium hydrogensulfite; In methanol; at 15 - 20 ℃;

upstream raw materials:

3,5-diiodo-DL-thyronine

3,5-diiodo-l-tyrosine

3,5-diiodo-L-thyronine

N-acetyl-3,5-diiodo-L-tyrosine

Downstream raw materials:

(S)-2-acetamido-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid

(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid

3,3'-diiodo-L-thyronine sulfate

L-Triiodothyronine sulfate