1-(4-chloro-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine

Base Information

• Chemical Name: 1-(4-chloro-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine
• CAS No.: 1018837-96-1
• Molecular Formula: C₂₆H₃₁ClN₆O₄
• Molecular Weight: 527.023
• Mol file: 1018837-96-1.mol

Synonyms:1-(4-chloro-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine

Chemical Property of 1-(4-chloro-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chloro-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine

There total 1 articles about 1-(4-chloro-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.7%

C27H32ClN3O5 (1018838-12-4) + guanidine nitrate (113-00-8) → 1-(4-chloro-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine (1018837-96-1)

Guidance literature:

In isopropyl alcohol; at 20 ℃;

DOI:10.1002/cbdv.200800268

Reference yield: 52.7%

1-(4-chloro-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine (1018837-96-1) + 4-Ethoxyaniline (156-43-4) → 1-(4-[(4-ethoxyphenyl)amino]-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine tetrahydrochloride

Guidance literature:

1-(4-chloro-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine; 4-Ethoxyaniline; With potassium carbonate; In isopropyl alcohol; for 3h; Reflux;

With hydrogenchloride; In ethyl acetate;

DOI:10.1002/cbdv.200800268

Reference yield: 46.1%

1-(4-chloro-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine (1018837-96-1) + 4-amino-o-xylene (95-64-7) → 1-(4-[(3,4-dimethylphenyl)amino]-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine tetrahydrochloride

Guidance literature:

1-(4-chloro-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine; 4-amino-o-xylene; With potassium carbonate; In isopropyl alcohol; for 3h; Reflux;

With hydrogenchloride; In ethyl acetate;

DOI:10.1002/cbdv.200800268

upstream raw materials:

C₂₇H₃₂ClN₃O₅

guanidine nitrate

Downstream raw materials:

1-(4-[(4-methoxyphenyl)amino]-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine

1-(4-(m-toluidino)-6-{[4-(2,3,4-trimethoxybenzyl)piperazin-1-yl]methyl}quinoline-3-carbonyl)guanidine