diethyl 4,4′-{7-[(4-hydroxyphenyl)ethynyl]-2-methyl-1H-indole-1,3-diyl}dibutanoate

Base Information

Chemical Name:diethyl 4,4′-{7-[(4-hydroxyphenyl)ethynyl]-2-methyl-1H-indole-1,3-diyl}dibutanoate
CAS No.:1232860-70-6
Molecular Formula:C₂₉H₃₃NO₅
Molecular Weight:475.585
Hs Code.:

Synonyms:diethyl 4,4′-{7-[(4-hydroxyphenyl)ethynyl]-2-methyl-1H-indole-1,3-diyl}dibutanoate

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Chemical Property of diethyl 4,4′-{7-[(4-hydroxyphenyl)ethynyl]-2-methyl-1H-indole-1,3-diyl}dibutanoate

Chemical Property:

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Technology Process of diethyl 4,4′-{7-[(4-hydroxyphenyl)ethynyl]-2-methyl-1H-indole-1,3-diyl}dibutanoate

There total 8 articles about diethyl 4,4′-{7-[(4-hydroxyphenyl)ethynyl]-2-methyl-1H-indole-1,3-diyl}dibutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232860-68-2
diethyl 4,4'-(7-{[4-(acetyloxy)phenyl]ethynyl}-2-methyl-1H-indole-1,3-diyl)dibutanoate

: 1232860-70-6
diethyl 4,4′-{7-[(4-hydroxyphenyl)ethynyl]-2-methyl-1H-indole-1,3-diyl}dibutanoate

Guidance literature:: With ethanol; potassium carbonate; In 1,2-dimethoxyethane; at 20 ℃; for 15h;

Reference yield:

: 3128-07-2
6-oxoheptanoic acid

: 1232860-70-6
diethyl 4,4′-{7-[(4-hydroxyphenyl)ethynyl]-2-methyl-1H-indole-1,3-diyl}dibutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 0.67 h / 50 °C

1.2: 16 h / Reflux

2.1: caesium carbonate / dimethyl sulfoxide / 16 h / 50 °C

3.1: diisopropylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / acetonitrile / 15 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / ethanol; 1,2-dimethoxyethane / 15 h / 20 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium carbonate; caesium carbonate; diisopropylamine; In 1,2-dimethoxyethane; ethanol; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1232860-64-8
ethyl 4-(7-bromo-2-methyl-1H-indol-3-yl)butanoate

: 1232860-70-6
diethyl 4,4′-{7-[(4-hydroxyphenyl)ethynyl]-2-methyl-1H-indole-1,3-diyl}dibutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / dimethyl sulfoxide / 16 h / 50 °C

2: diisopropylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / acetonitrile / 15 h / 20 °C / Inert atmosphere

3: potassium carbonate / ethanol; 1,2-dimethoxyethane / 15 h / 20 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium carbonate; caesium carbonate; diisopropylamine; In 1,2-dimethoxyethane; ethanol; dimethyl sulfoxide; acetonitrile;