[3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridin-2-yl)-phenyl]-methanol

Base Information

Chemical Name:[3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridin-2-yl)-phenyl]-methanol
CAS No.:1365992-13-7
Molecular Formula:C₁₃H₇Cl₃N₂OS
Molecular Weight:345.636
Hs Code.:

Synonyms:[3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridin-2-yl)-phenyl]-methanol

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Chemical Property of [3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridin-2-yl)-phenyl]-methanol

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Technology Process of [3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridin-2-yl)-phenyl]-methanol

There total 10 articles about [3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridin-2-yl)-phenyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1365992-12-6
3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridin-2-yl)-benzaldehyde

: 1365992-13-7
[3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridin-2-yl)-phenyl]-methanol

Guidance literature:: 3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridin-2-yl)-benzaldehyde; With sodium cyanoborohydride; acetic acid; In methanol; dichloromethane; for 2h;

With sodium hydrogencarbonate; In methanol; dichloromethane; water;

Reference yield:

: 628691-93-0
2-chloro-3-fluoro-pyridine-4-carboxylic acid

: 1365992-13-7
[3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridin-2-yl)-phenyl]-methanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: diphenyl phosphoryl azide / toluene / 3 h / 110 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2.2: NH₂ cartridge

3.1: triethylamine / 1,4-dioxane / 18 h / 100 °C

4.1: thionyl chloride / 56 h / 90 °C

5.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / 90 °C

5.2: 1.5 h / 90 °C

6.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

7.1: ozone / dichloromethane; methanol / 0.17 h / -78 °C

7.2: -78 - 20 °C / Inert atmosphere

8.1: sodium cyanoborohydride; acetic acid / dichloromethane; methanol / 2 h

With pyridine; thionyl chloride; diphenyl phosphoryl azide; sodium cyanoborohydride; sodium carbonate; ozone; acetic acid; triethylamine; thiourea; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol; toluene;

Reference yield:

: 1258298-01-9
2,6-dichloro-4-iodo-benzoic acid

: 1365992-13-7
[3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridin-2-yl)-phenyl]-methanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine / 1,4-dioxane / 18 h / 100 °C

3.1: thionyl chloride / 56 h / 90 °C

4.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / 90 °C

4.2: 1.5 h / 90 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

6.1: ozone / dichloromethane; methanol / 0.17 h / -78 °C

6.2: -78 - 20 °C / Inert atmosphere

7.1: sodium cyanoborohydride; acetic acid / dichloromethane; methanol / 2 h

With pyridine; thionyl chloride; sodium cyanoborohydride; sodium carbonate; ozone; acetic acid; triethylamine; thiourea; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol;