tert-butyl cyclopropyl((1-(4-nitrophenyl)cyclopropyl)methyl)carbamate

Base Information

• Chemical Name: tert-butyl cyclopropyl((1-(4-nitrophenyl)cyclopropyl)methyl)carbamate
• CAS No.: 1308815-47-5
• Molecular Formula: C₁₈H₂₄N₂O₄
• Molecular Weight: 332.4
• Mol file: 1308815-47-5.mol

Synonyms:tert-butyl cyclopropyl((1-(4-nitrophenyl)cyclopropyl)methyl)carbamate

Chemical Property of tert-butyl cyclopropyl((1-(4-nitrophenyl)cyclopropyl)methyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl cyclopropyl((1-(4-nitrophenyl)cyclopropyl)methyl)carbamate

There total 4 articles about tert-butyl cyclopropyl((1-(4-nitrophenyl)cyclopropyl)methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

di-tert-butyl dicarbonate (24424-99-5) + N-((1-(4-nitrophenyl)cyclopropyl)methyl)cyclopropanamine (1308815-46-4) → tert-butyl cyclopropyl((1-(4-nitrophenyl)cyclopropyl)methyl)carbamate (1308815-47-5)

Guidance literature:

In ethyl acetate; at 20 ℃; for 4h;

Reference yield:

1-(4-nitrophenyl)cyclopropane-1-carboxylic acid (23348-99-4) → tert-butyl cyclopropyl((1-(4-nitrophenyl)cyclopropyl)methyl)carbamate (1308815-47-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine; methyl chloroformate / tetrahydrofuran / 0 - 10 °C / Inert atmosphere

1.2: 1 h / 0 °C

2.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C

3.1: sodium hydrogencarbonate / acetonitrile / 5 h / 20 - 70 °C

4.1: ethyl acetate / 4 h / 20 °C

With sodium hydrogencarbonate; triethylamine; methyl chloroformate; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

1-(4-nitrophenyl)-hydroxymethylcyclopropane (23349-00-0) → tert-butyl cyclopropyl((1-(4-nitrophenyl)cyclopropyl)methyl)carbamate (1308815-47-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1 h / 0 - 5 °C

2: sodium hydrogencarbonate / acetonitrile / 5 h / 20 - 70 °C

3: ethyl acetate / 4 h / 20 °C

With sodium hydrogencarbonate; triethylamine; In dichloromethane; ethyl acetate; acetonitrile;

upstream raw materials:

di-tert-butyl dicarbonate

N-((1-(4-nitrophenyl)cyclopropyl)methyl)cyclopropanamine

1-(4-nitrophenyl)cyclopropane-1-carboxylic acid

1-(4-nitrophenyl)-hydroxymethylcyclopropane

Downstream raw materials:

tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate

tert-butyl ((1-(4-aminophenyl)cyclopropyl)methyl)(cyclopropyl)carbamate