7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide

Base Information

Chemical Name:7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide
CAS No.:1086423-54-2
Molecular Formula:C₂₂H₁₆F₃N₅O₂
Molecular Weight:439.397
Hs Code.:

Synonyms:7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide

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Chemical Property of 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide

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Technology Process of 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide

There total 6 articles about 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1086423-57-5
7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide

: 1086423-54-2
7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide

Guidance literature:: With sodium amalgam; 2,2,2-trifluoroethanol; In tetrahydrofuran; for 0.25h;

Reference yield:

: 1005206-16-5
7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile

: 1086423-54-2
7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dmap / dichloromethane / 1 h

2: hydrogenchloride; water / 1.5 h / 100 °C

3: oxalyl dichloride / dichloromethane / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h

5: sodium amalgam; 2,2,2-trifluoroethanol / tetrahydrofuran / 0.25 h

With hydrogenchloride; sodium amalgam; oxalyl dichloride; 2,2,2-trifluoroethanol; water; triethylamine; N-ethyl-N,N-diisopropylamine; dmap; In tetrahydrofuran; dichloromethane;

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1086423-54-2
7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1: dimethyl sulfoxide / 8 h / 150 °C

2: triethylamine / dmap / dichloromethane / 1 h

3: hydrogenchloride; water / 1.5 h / 100 °C

4: oxalyl dichloride / dichloromethane / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h

6: sodium amalgam; 2,2,2-trifluoroethanol / tetrahydrofuran / 0.25 h

With hydrogenchloride; sodium amalgam; oxalyl dichloride; 2,2,2-trifluoroethanol; water; triethylamine; N-ethyl-N,N-diisopropylamine; dmap; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;