7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

Base Information

• Chemical Name: 7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid
• CAS No.: 1086423-56-4
• Molecular Formula: C₁₄H₁₁N₃O₄S
• Molecular Weight: 317.325
• Mol file: 1086423-56-4.mol

Synonyms:7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

Chemical Property of 7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

There total 3 articles about 7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile (1086423-55-3) → 7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid (1086423-56-4)

Guidance literature:

With hydrogenchloride; water; at 100 ℃; for 1.5h;

Reference yield:

7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile (1005206-16-5) → 7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid (1086423-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dmap / dichloromethane / 1 h

2: hydrogenchloride; water / 1.5 h / 100 °C

With hydrogenchloride; water; triethylamine; dmap; In dichloromethane;

Reference yield:

4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → 7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid (1086423-56-4)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethyl sulfoxide / 8 h / 150 °C

2: triethylamine / dmap / dichloromethane / 1 h

3: hydrogenchloride; water / 1.5 h / 100 °C

With hydrogenchloride; water; triethylamine; dmap; In dichloromethane; dimethyl sulfoxide;

upstream raw materials:

7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile

7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide

7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide