((2S,3S)-3-Benzyloxymethyl-3-vinyl-oxiranylmethoxy)-dimethyl-(1,1,2-trimethyl-propyl)-silane

Base Information

Chemical Name:((2S,3S)-3-Benzyloxymethyl-3-vinyl-oxiranylmethoxy)-dimethyl-(1,1,2-trimethyl-propyl)-silane
CAS No.:190896-58-3
Molecular Formula:C₂₁H₃₄O₃Si
Molecular Weight:362.585
Hs Code.:

Synonyms:((2S,3S)-3-Benzyloxymethyl-3-vinyl-oxiranylmethoxy)-dimethyl-(1,1,2-trimethyl-propyl)-silane

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Chemical Property of ((2S,3S)-3-Benzyloxymethyl-3-vinyl-oxiranylmethoxy)-dimethyl-(1,1,2-trimethyl-propyl)-silane

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Technology Process of ((2S,3S)-3-Benzyloxymethyl-3-vinyl-oxiranylmethoxy)-dimethyl-(1,1,2-trimethyl-propyl)-silane

There total 8 articles about ((2S,3S)-3-Benzyloxymethyl-3-vinyl-oxiranylmethoxy)-dimethyl-(1,1,2-trimethyl-propyl)-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 190896-64-1
(2S,3S)-2-Benzyloxymethyl-3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-oxirane-2-carbaldehyde

: 190896-58-3
((2S,3S)-3-Benzyloxymethyl-3-vinyl-oxiranylmethoxy)-dimethyl-(1,1,2-trimethyl-propyl)-silane

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 1.5h;
DOI:10.1016/S0040-4020(97)00453-5

Reference yield:

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 190896-58-3
((2S,3S)-3-Benzyloxymethyl-3-vinyl-oxiranylmethoxy)-dimethyl-(1,1,2-trimethyl-propyl)-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / CF₃SO₃H / hexane; CH₂Cl₂ / 0.42 h / Heating

2: 95 percent / diisobutylaluminum hydride / diethyl ether; hexane / 1.) -78 deg C, 25 min, 2.) 0 deg C, 2 h, then 25 deg C, 2 h

3: 7.44 g / n-BuLi / tetrahydrofuran; hexane / 5 h / Ambient temperature

4: 92 percent / D-(-)-diethyl tartrate, Ti(O-i-Pr)4, TBHP / CH₂Cl₂; 2,2,4-trimethyl-pentane / 4 h / -20 °C

5: 5.5 g / oxalyl chloride, DMSO / CH₂Cl₂ / 1 h / -78 °C

6: 63 percent / n-BuLi / tetrahydrofuran; hexane / 1.5 h / 0 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; n-butyllithium; oxalyl dichloride; diethyl (2S,3S)-tartrate; trifluorormethanesulfonic acid; diisobutylaluminium hydride; dimethyl sulfoxide; In tetrahydrofuran; 2,2,4-trimethylpentane; diethyl ether; hexane; dichloromethane;
DOI:10.1016/S0040-4020(97)00453-5

Reference yield:

: 80904-75-2
4-hydroxymethyl-5H-furan-2-one

: 190896-58-3
((2S,3S)-3-Benzyloxymethyl-3-vinyl-oxiranylmethoxy)-dimethyl-(1,1,2-trimethyl-propyl)-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / CF₃SO₃H / hexane; CH₂Cl₂ / 0.42 h / Heating

2: 95 percent / diisobutylaluminum hydride / diethyl ether; hexane / 1.) -78 deg C, 25 min, 2.) 0 deg C, 2 h, then 25 deg C, 2 h

3: 7.44 g / n-BuLi / tetrahydrofuran; hexane / 5 h / Ambient temperature

4: 92 percent / D-(-)-diethyl tartrate, Ti(O-i-Pr)4, TBHP / CH₂Cl₂; 2,2,4-trimethyl-pentane / 4 h / -20 °C

5: 5.5 g / oxalyl chloride, DMSO / CH₂Cl₂ / 1 h / -78 °C

6: 63 percent / n-BuLi / tetrahydrofuran; hexane / 1.5 h / 0 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; n-butyllithium; oxalyl dichloride; diethyl (2S,3S)-tartrate; trifluorormethanesulfonic acid; diisobutylaluminium hydride; dimethyl sulfoxide; In tetrahydrofuran; 2,2,4-trimethylpentane; diethyl ether; hexane; dichloromethane;
DOI:10.1016/S0040-4020(97)00453-5