4-(p-carbomethoxyphenyl)hexanal

Base Information

• Chemical Name: 4-(p-carbomethoxyphenyl)hexanal
• CAS No.: 123751-66-6
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.295
• Mol file: 123751-66-6.mol

Synonyms:4-(p-carbomethoxyphenyl)hexanal

Chemical Property of 4-(p-carbomethoxyphenyl)hexanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(p-carbomethoxyphenyl)hexanal

There total 6 articles about 4-(p-carbomethoxyphenyl)hexanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-((E)-1-Ethyl-4-methoxy-but-3-enyl)-benzoic acid methyl ester (123751-64-4) → 4-(p-carbomethoxyphenyl)hexanal (123751-66-6)

Guidance literature:

With hydrogenchloride; In acetic acid; for 18h; Ambient temperature;

DOI:10.1021/jm00164a033

Reference yield:

4-n-propylbenzoic acid (2438-05-3) → 4-(p-carbomethoxyphenyl)hexanal (123751-66-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) LDA, HMPA / 1.) THF, hexane, a) 0-5 deg C, 6 h, b) RT temp., 22 h, 2.) 0-5 deg C

2: 28 percent / NaHCO₃ / dimethylformamide / 72 h / Ambient temperature

3: 97 percent / 1N HCl / acetic acid / 18 h / Ambient temperature

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydrogencarbonate; lithium diisopropyl amide; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00164a033

Reference yield:

4-((E)-1-Ethyl-4-methoxy-but-3-enyl)-benzoic acid (123751-62-2) → 4-(p-carbomethoxyphenyl)hexanal (123751-66-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 28 percent / NaHCO₃ / dimethylformamide / 72 h / Ambient temperature

2: 97 percent / 1N HCl / acetic acid / 18 h / Ambient temperature

With hydrogenchloride; sodium hydrogencarbonate; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00164a033

upstream raw materials:

4-((E)-1-Ethyl-4-methoxy-but-3-enyl)-benzoic acid methyl ester

4-n-propylbenzoic acid

4-((E)-1-Ethyl-4-methoxy-but-3-enyl)-benzoic acid

(E)-3-hexen-1-ol

Downstream raw materials:

4-[1-(6-Amino-5-cyano-pyridin-3-ylmethyl)-propyl]-benzoic acid methyl ester

10-ethyl-5,10-dideazapteroic acid

4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoic acid

4-{5,5-Dicyano-1-ethyl-3-[1-piperidin-1-yl-meth-(E)-ylidene]-pent-4-enyl}-benzoic acid methyl ester

Refernces

• 1、 Mei, Tian-Sheng,Werner, Erik W.,Burckle, Alexander J.,Sigman, Matthew S.. "Enantioselective redox-relay oxidative heck arylations of acyclic alkenyl alcohols using boronic acids". supporting information. p. 6830 - 6833. Retrieved 2013/06/05.