10-ethyl-5,10-dideazapteroic acid

Base Information

Chemical Name:10-ethyl-5,10-dideazapteroic acid
CAS No.:123751-75-7
Molecular Formula:C₁₈H₁₈N₄O₃
Molecular Weight:338.366
Hs Code.:

Synonyms:10-ethyl-5,10-dideazapteroic acid

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Chemical Property of 10-ethyl-5,10-dideazapteroic acid

Chemical Property:

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Technology Process of 10-ethyl-5,10-dideazapteroic acid

There total 7 articles about 10-ethyl-5,10-dideazapteroic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 123751-73-5
4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoic acid

: 123751-75-7
10-ethyl-5,10-dideazapteroic acid

Guidance literature:: With sodium hydroxide; for 2.5h; Heating;
DOI:10.1021/jm00164a033

Reference yield:

: 2438-05-3
4-n-propylbenzoic acid

: 123751-75-7
10-ethyl-5,10-dideazapteroic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) LDA, HMPA / 1.) THF, hexane, a) 0-5 deg C, 6 h, b) RT temp., 22 h, 2.) 0-5 deg C

2: 28 percent / NaHCO₃ / dimethylformamide / 72 h / Ambient temperature

3: 97 percent / 1N HCl / acetic acid / 18 h / Ambient temperature

4: K₂CO₃ / 0.67 h / 60 °C

5: Et₃N / tetrahydrofuran / 1.) -20 deg C, 2.) RT, 15 h

6: 73 percent / conc. NH₄OH / methanol / 72 h / Ambient temperature

7: 1.) Na, 2.) H₂O / 1.) 2-methoxyethanol, 115-120 deg C, 24 h, 2.) 100 deg C, 4 h

8: 94 percent / 10percent NaOH / 2.5 h / Heating

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium hydroxide; sodium hydroxide; water; sodium; sodium hydrogencarbonate; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00164a033

Reference yield:

: 123751-66-6
4-(p-carbomethoxyphenyl)hexanal

: 123751-75-7
10-ethyl-5,10-dideazapteroic acid

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / 0.67 h / 60 °C

2: Et₃N / tetrahydrofuran / 1.) -20 deg C, 2.) RT, 15 h

3: 73 percent / conc. NH₄OH / methanol / 72 h / Ambient temperature

4: 1.) Na, 2.) H₂O / 1.) 2-methoxyethanol, 115-120 deg C, 24 h, 2.) 100 deg C, 4 h

5: 94 percent / 10percent NaOH / 2.5 h / Heating

With ammonium hydroxide; sodium hydroxide; water; sodium; potassium carbonate; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jm00164a033