8-Chloro-11-(1-((3-nitrophenyl)sulfonyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta-[1,2-b]pyridine

Base Information

• Chemical Name: 8-Chloro-11-(1-((3-nitrophenyl)sulfonyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta-[1,2-b]pyridine
• CAS No.: 1423771-99-6
• Molecular Formula: C₂₅H₂₂ClN₃O₄S
• Molecular Weight: 495.986
• Mol file: 1423771-99-6.mol

Synonyms:8-Chloro-11-(1-((3-nitrophenyl)sulfonyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta-[1,2-b]pyridine

Chemical Property of 8-Chloro-11-(1-((3-nitrophenyl)sulfonyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta-[1,2-b]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-Chloro-11-(1-((3-nitrophenyl)sulfonyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta-[1,2-b]pyridine

There total 1 articles about 8-Chloro-11-(1-((3-nitrophenyl)sulfonyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta-[1,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

descarboethoxyloratadine (100643-71-8) + 3-nitrobenzenesulphonyl chloride (121-51-7) → 8-Chloro-11-(1-((3-nitrophenyl)sulfonyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta-[1,2-b]pyridine (1423771-99-6)

Guidance literature:

descarboethoxyloratadine; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;

3-nitrobenzenesulphonyl chloride; In dichloromethane; for 2h;

DOI:10.3390/molecules19022694

Reference yield: 83.1%

8-Chloro-11-(1-((3-nitrophenyl)sulfonyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta-[1,2-b]pyridine (1423771-99-6) → 3-((4-(8-Chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)sulfonyl)aniline (1620727-53-8)

Guidance literature:

With 5%-palladium/activated carbon; hydrazine hydrate; In methanol; for 3h; Reflux;

Reference yield:

8-Chloro-11-(1-((3-nitrophenyl)sulfonyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta-[1,2-b]pyridine (1423771-99-6) → N-(3-((4-(8-Chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)sulfonyl)phenyl)-4-methylbenzenesulfonamide (1620882-48-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; tin(ll) chloride / ethanol / Reflux

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C

2.2: 3 h

With hydrogenchloride; triethylamine; tin(ll) chloride; In ethanol; dichloromethane;

DOI:10.3390/molecules19022694

upstream raw materials:

descarboethoxyloratadine

3-nitrobenzenesulphonyl chloride

Downstream raw materials:

N-(3-((4-(8-Chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)sulfonyl)phenyl)-3-nitrobenzamide

N-(3-((4-(8-Chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)sulfonyl)phenyl)-4-methylbenzenesulfonamide

3-((4-(8-Chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)sulfonyl)aniline

N-(3-((4-(8-Chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)sulfonyl)phenyl)butyramide