N-hydroxy-1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxamidine

Base Information

Chemical Name:N-hydroxy-1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxamidine
CAS No.:1518920-12-1
Molecular Formula:C₁₅H₁₁F₃N₄O₂
Molecular Weight:336.273
Hs Code.:

Synonyms:N-hydroxy-1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxamidine

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Chemical Property of N-hydroxy-1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxamidine

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Technology Process of N-hydroxy-1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxamidine

There total 5 articles about N-hydroxy-1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1518920-10-9
1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbonitrile

: 1518920-12-1
N-hydroxy-1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxamidine

Guidance literature:: With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; at 45 ℃; for 48h;

Reference yield:

: 934-07-6
5-bromo-1H-pyrrole-2-carboxylic acid methyl ester

: 1518920-12-1
N-hydroxy-1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxamidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: ammonium acetate; acetic acid / 130 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere; Sealed tube

3.2: 1 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

4.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; dichloromethane; methanol / 48 h / 45 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydroxylamine hydrochloride; ammonium acetate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; XPhos; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1518920-27-8
6-bromo-3-(4-trifluoromethylphenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one

: 1518920-12-1
N-hydroxy-1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carboxamidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere; Sealed tube

1.2: 1 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

2.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; dichloromethane; methanol / 48 h / 45 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; XPhos; In methanol; dichloromethane; N,N-dimethyl-formamide;