1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbonitrile

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Chemical Name:1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbonitrile
CAS No.:1518920-10-9
Molecular Formula:C₁₅H₈F₃N₃O
Molecular Weight:303.243
Hs Code.:

Synonyms:1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbonitrile

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Chemical Property of 1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbonitrile

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Technology Process of 1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbonitrile

There total 4 articles about 1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 557-21-1
zinc(II) cyanide

: 1518920-27-8
6-bromo-3-(4-trifluoromethylphenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one

: 1518920-10-9
1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbonitrile

Guidance literature:: zinc(II) cyanide; 6-bromo-3-(4-trifluoromethylphenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In N,N-dimethyl-formamide; at 100 ℃; for 24h; Inert atmosphere; Sealed tube;

In N,N-dimethyl-formamide; at 130 ℃; for 1h; Inert atmosphere; Microwave irradiation; Sealed tube;

Reference yield:

: 934-07-6
5-bromo-1H-pyrrole-2-carboxylic acid methyl ester

: 1518920-10-9
1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: ammonium acetate; acetic acid / 130 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere; Sealed tube

3.2: 1 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonium acetate; potassium carbonate; acetic acid; XPhos; In N,N-dimethyl-formamide;

Reference yield:

: 5-bromo-1-[2-oxo-2-(4-trifluoromethylphenyl)-ethyl]-1H-pyrrole-2-carboxylic acid methyl ester

: 1518920-10-9
1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate; acetic acid / 130 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere; Sealed tube

2.2: 1 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonium acetate; acetic acid; XPhos; In N,N-dimethyl-formamide;