(3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

Base Information

Chemical Name:(3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol
CAS No.:1202578-18-4
Molecular Formula:C₂₂H₂₈O₃
Molecular Weight:340.463
Hs Code.:

Synonyms:(3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

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Chemical Property of (3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

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Technology Process of (3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

There total 12 articles about (3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1202578-17-3
{[(3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropyl]oxy}(triisopropyl)silane

: 1202578-18-4
(3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 15764-16-6
2,4-dimethylbenzaldehyde

: 1202578-18-4
(3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: hydrogen / ethanol / 20 °C

2.2: 20 °C

3.1: polyphosphoric acid / water / 1 h / 90 °C / Cooling with ice

4.1: triethylamine; formic acid / Noyori's catalyst / dichloromethane / 20 - 40 °C / Inert atmosphere

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toleuene / 20 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

With formic acid; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; Noyori's catalyst; In tetrahydrofuran; ethanol; dichloromethane; toleuene; water;

Reference yield:

: 1811-85-4
3-(2,4-dimethylphenyl)propionic acid

: 1202578-18-4
(3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: polyphosphoric acid / water / 1 h / 90 °C / Cooling with ice

2: triethylamine; formic acid / Noyori's catalyst / dichloromethane / 20 - 40 °C / Inert atmosphere

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toleuene / 20 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

With formic acid; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; diethylazodicarboxylate; Noyori's catalyst; In tetrahydrofuran; dichloromethane; toleuene; water;