(2R,3R)-3-hydroxy-2-methyl-3-(4-nitrophenyl)-2-o-tolylpropanoic acid

Base Information

Chemical Name:(2R,3R)-3-hydroxy-2-methyl-3-(4-nitrophenyl)-2-o-tolylpropanoic acid
CAS No.:1224226-08-7
Molecular Formula:C₁₇H₁₇NO₅
Molecular Weight:315.326
Hs Code.:

Synonyms:(2R,3R)-3-hydroxy-2-methyl-3-(4-nitrophenyl)-2-o-tolylpropanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-3-hydroxy-2-methyl-3-(4-nitrophenyl)-2-o-tolylpropanoic acid

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Technology Process of (2R,3R)-3-hydroxy-2-methyl-3-(4-nitrophenyl)-2-o-tolylpropanoic acid

There total 2 articles about (2R,3R)-3-hydroxy-2-methyl-3-(4-nitrophenyl)-2-o-tolylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 945666-91-1
o-tolyl methyl ketene

: 555-16-8
4-nitrobenzaldehdye

: 1224226-08-7
(2R,3R)-3-hydroxy-2-methyl-3-(4-nitrophenyl)-2-o-tolylpropanoic acid

Guidance literature:: o-tolyl methyl ketene; 4-nitrobenzaldehdye; With (R)-BINAPHANE; In dichloromethane; at -78 - 20 ℃; for 12h; Inert atmosphere;

With potassium hydroxide; In tetrahydrofuran; water; at 60 ℃; for 5h; optical yield given as %de;
DOI:10.1021/ol100075m