945666-91-1

Upstream product

• 137144-15-1 (rac)-2-(2-methylphenyl)propanoic acid 

Downstream Products

• 1224225-82-4 (3R,4R)-3-methyl-4-(4-nitrophenyl)-3-o-tolyloxetan-2-one 
• 1224226-08-7 (2R,3R)-3-hydroxy-2-methyl-3-(4-nitrophenyl)-2-o-tolylpropanoic acid 
• 1255944-71-8 Z-3-methyl-3-o-tolyl-4-(1-o-tolylethylidene)oxetan-2-one 
• 1158774-63-0 4-methyl-4-o-tolyl-2-(2-(trifluoromethyl)phenyl)-1,2-oxazetidin-3-one 

Relevant academic research and scientific papers

Stereo- and Chemodivergent NHC-Promoted Functionalisation of Arylalkylketenes with Chloral

Stereo- and chemodivergent enantioselective reaction pathways are observed upon treatment of alkylarylketenes and trichloroacetaldehyde (chloral) with N-heterocyclic carbenes, giving selectively either β-lactones (up to 88:12 dr, up to 94% ee) or α-chloroesters (up to 94% ee). Either 2-arylsubstitution or an α-branched iPr alkyl substituent within the ketene favours the chlorination pathway, allowing chloral to be used as an electrophilic chlorinating reagent in asymmetric catalysis.