(R/S)-2-hydroxy-N-(2-oxo-2-(1,1-dioxide-tetrahydrothiophen-3-ylamino)ethyl)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

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Chemical Name:(R/S)-2-hydroxy-N-(2-oxo-2-(1,1-dioxide-tetrahydrothiophen-3-ylamino)ethyl)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide
CAS No.:1344706-41-7
Molecular Formula:C₂₆H₂₂F₃N₅O₇S
Molecular Weight:605.551
Hs Code.:

(R/S)-2-hydroxy-N-(2-oxo-2-(1,1-dioxide-tetrahydrothiophen-3-ylamino)ethyl)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Synonyms:(R/S)-2-hydroxy-N-(2-oxo-2-(1,1-dioxide-tetrahydrothiophen-3-ylamino)ethyl)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

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Chemical Property of (R/S)-2-hydroxy-N-(2-oxo-2-(1,1-dioxide-tetrahydrothiophen-3-ylamino)ethyl)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

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Technology Process of (R/S)-2-hydroxy-N-(2-oxo-2-(1,1-dioxide-tetrahydrothiophen-3-ylamino)ethyl)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

There total 12 articles about (R/S)-2-hydroxy-N-(2-oxo-2-(1,1-dioxide-tetrahydrothiophen-3-ylamino)ethyl)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.4%

: 1344708-52-6
(R/S)-2-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetic acid

: 6338-70-1
3-amino-tetrahydrothiophene 1,1-dioxide

: 1344706-41-7
(R/S)-2-hydroxy-N-(2-oxo-2-(1,1-dioxide-tetrahydrothiophen-3-ylamino)ethyl)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1344706-41-7
(R/S)-2-hydroxy-N-(2-oxo-2-(1,1-dioxide-tetrahydrothiophen-3-ylamino)ethyl)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2: triethylamine / 1,2-dichloro-ethane / 20 - 70 °C

3: Jones reagent / acetone / 20 °C

4: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile

6: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

7: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide

8: trifluoroacetic acid / dichloromethane / 1 h

9: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide

With 4-methyl-morpholine; pyridine; N-chloro-succinimide; Jones reagent; trifluoro-[1,3,5]triazine; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 934-16-7
phenylhydroxamoyl chloride

: 1344706-41-7
(R/S)-2-hydroxy-N-(2-oxo-2-(1,1-dioxide-tetrahydrothiophen-3-ylamino)ethyl)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / 1,2-dichloro-ethane / 20 - 70 °C

2: Jones reagent / acetone / 20 °C

3: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile

5: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

6: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide

7: trifluoroacetic acid / dichloromethane / 1 h

8: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide

With 4-methyl-morpholine; pyridine; Jones reagent; trifluoro-[1,3,5]triazine; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;