7-chloro-3-(2-chlorobenzyl)-1-(4-methoxybenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Chemical Name:7-chloro-3-(2-chlorobenzyl)-1-(4-methoxybenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS No.:1059066-15-7
Molecular Formula:C₃₁H₂₄Cl₂N₄O₃
Molecular Weight:571.463
Hs Code.:

Synonyms:7-chloro-3-(2-chlorobenzyl)-1-(4-methoxybenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Chemical Property of 7-chloro-3-(2-chlorobenzyl)-1-(4-methoxybenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Technology Process of 7-chloro-3-(2-chlorobenzyl)-1-(4-methoxybenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

There total 4 articles about 7-chloro-3-(2-chlorobenzyl)-1-(4-methoxybenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4743-17-3
5-Chloroisatoic anhydride

: 1059066-15-7
7-chloro-3-(2-chlorobenzyl)-1-(4-methoxybenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / acetonitrile; water

1.2: 20 °C

1.3: 6 h / 130 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 4 h / 90 °C / Inert atmosphere

4.1: lithium chloride; cesiumhydroxide monohydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

With cesiumhydroxide monohydrate; potassium carbonate; N,N-dimethyl-aniline; triethylamine; lithium chloride; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 120108-63-6,185030-83-5
2-amino-3-(2-chlorophenyl)propionic acid hydrochloride

: 1059066-15-7
7-chloro-3-(2-chlorobenzyl)-1-(4-methoxybenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / acetonitrile; water

1.2: 20 °C

1.3: 6 h / 130 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 4 h / 90 °C / Inert atmosphere

4.1: lithium chloride; cesiumhydroxide monohydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

With cesiumhydroxide monohydrate; potassium carbonate; N,N-dimethyl-aniline; triethylamine; lithium chloride; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1059065-39-2
7-chloro-3-(2-chlorobenzyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

: 1059066-15-7
7-chloro-3-(2-chlorobenzyl)-1-(4-methoxybenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: trichlorophosphate; N,N-dimethyl-aniline / toluene / 4 h / 90 °C / Inert atmosphere

3: lithium chloride; cesiumhydroxide monohydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

With cesiumhydroxide monohydrate; potassium carbonate; N,N-dimethyl-aniline; lithium chloride; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;