7-chloro-3-(2-chlorobenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Chemical Name:7-chloro-3-(2-chlorobenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS No.:1059064-18-4
Molecular Formula:C₂₃H₁₆Cl₂N₄O₂
Molecular Weight:451.312
Hs Code.:

Synonyms:7-chloro-3-(2-chlorobenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Chemical Property of 7-chloro-3-(2-chlorobenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Technology Process of 7-chloro-3-(2-chlorobenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

There total 5 articles about 7-chloro-3-(2-chlorobenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1059066-15-7
7-chloro-3-(2-chlorobenzyl)-1-(4-methoxybenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1059064-18-4
7-chloro-3-(2-chlorobenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: With aluminum (III) chloride; In methoxybenzene; at 85 ℃; for 1h; Inert atmosphere;

Reference yield:

: 4743-17-3
5-Chloroisatoic anhydride

: 1059064-18-4
7-chloro-3-(2-chlorobenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / acetonitrile; water

1.2: 20 °C

1.3: 6 h / 130 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 4 h / 90 °C / Inert atmosphere

4.1: lithium chloride; cesiumhydroxide monohydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

5.1: aluminum (III) chloride / methoxybenzene / 1 h / 85 °C / Inert atmosphere

With aluminum (III) chloride; cesiumhydroxide monohydrate; potassium carbonate; N,N-dimethyl-aniline; triethylamine; lithium chloride; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; methoxybenzene; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1059065-40-5
7-chloro-3-(2-chlorobenzyl)-1-(4-methoxybenzyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

: 1059064-18-4
7-chloro-3-(2-chlorobenzyl)-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 4 h / 90 °C / Inert atmosphere

2: lithium chloride; cesiumhydroxide monohydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

3: aluminum (III) chloride / methoxybenzene / 1 h / 85 °C / Inert atmosphere

With aluminum (III) chloride; cesiumhydroxide monohydrate; N,N-dimethyl-aniline; lithium chloride; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methoxybenzene; toluene;