cis-3'-(4-fluorophenyl)-4-methylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]

Base Information

Chemical Name:cis-3'-(4-fluorophenyl)-4-methylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]
CAS No.:78263-00-0
Molecular Formula:C₂₀H₂₂FNO
Molecular Weight:311.399
Hs Code.:

Synonyms:cis-3'-(4-fluorophenyl)-4-methylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]

Suppliers and Price of cis-3'-(4-fluorophenyl)-4-methylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cis-3'-(4-fluorophenyl)-4-methylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]

Chemical Property:

Purity/Quality:

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Technology Process of cis-3'-(4-fluorophenyl)-4-methylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]

There total 8 articles about cis-3'-(4-fluorophenyl)-4-methylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71-23-8
propan-1-ol

: cis-3'-(4-fluorophenyl)-4-methylphenoxycarbonylaminospiro[cyclohexane-1,1'-(3'H)-isobenzofuran]

: 78263-00-0
cis-3'-(4-fluorophenyl)-4-methylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]

Guidance literature:: With potassium hydroxide; In sodium hydroxide; water; isopropyl alcohol;

Reference yield:

: 93-98-1,5705-51-1
N-phenyl benzoyl amide

: 78263-00-0
[3'-(4-Fluoro-phenyl)-3'H-spiro[cyclohex-1,1'-isobenzofuran]-4-yl]-methyl-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 1 h, 2.) THF, a) -40 deg C, 0.75 h, b) 0 deg C, 1 h

2: 54 percent / tetrahydrofuran; benzene; diethyl ether / 1 h / 0 °C

3: 30 percent / 97percent formic acid / 2 h / Heating

4: 73 percent / CH₂Cl₂

5: KOH, ethylene glycol

With potassium hydroxide; n-butyllithium; formic acid; ethylene glycol; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;
DOI:10.1021/jm00137a025

Reference yield:

: 1493-23-8
(4-fluorophenyl)lithium

: 78263-00-0
[3'-(4-Fluoro-phenyl)-3'H-spiro[cyclohex-1,1'-isobenzofuran]-4-yl]-methyl-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 54 percent / tetrahydrofuran; benzene; diethyl ether / 1 h / 0 °C

2: 30 percent / 97percent formic acid / 2 h / Heating

3: 73 percent / CH₂Cl₂

4: KOH, ethylene glycol

With potassium hydroxide; formic acid; ethylene glycol; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;
DOI:10.1021/jm00137a025