4-[4-(4-amino-2,5-difluorophenyl)cyclohexylideneaminooxy]piperidin-1-carboxylic acid isopropyl ester

Base Information

Chemical Name:4-[4-(4-amino-2,5-difluorophenyl)cyclohexylideneaminooxy]piperidin-1-carboxylic acid isopropyl ester
CAS No.:1393685-92-1
Molecular Formula:C₂₁H₂₉F₂N₃O₃
Molecular Weight:409.476
Hs Code.:

Synonyms:4-[4-(4-amino-2,5-difluorophenyl)cyclohexylideneaminooxy]piperidin-1-carboxylic acid isopropyl ester

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Chemical Property of 4-[4-(4-amino-2,5-difluorophenyl)cyclohexylideneaminooxy]piperidin-1-carboxylic acid isopropyl ester

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Technology Process of 4-[4-(4-amino-2,5-difluorophenyl)cyclohexylideneaminooxy]piperidin-1-carboxylic acid isopropyl ester

There total 9 articles about 4-[4-(4-amino-2,5-difluorophenyl)cyclohexylideneaminooxy]piperidin-1-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1393685-68-1
4-[4-(4-amino-2,5-difluorophenyl)cyclohexylideneaminooxy]piperidin-1-carboxylic acid tert-butyl ester

: 108-23-6
isopropyl chloroformate

: 1393685-92-1
4-[4-(4-amino-2,5-difluorophenyl)cyclohexylideneaminooxy]piperidin-1-carboxylic acid isopropyl ester

Guidance literature:: 4-[4-(4-amino-2,5-difluorophenyl)cyclohexylideneaminooxy]piperidin-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 1h;

isopropyl chloroformate; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;

Reference yield:

: 167415-27-2
1-bromo-2,5-difluoro-4-nitrobenzene

: 1393685-92-1
4-[4-(4-amino-2,5-difluorophenyl)cyclohexylideneaminooxy]piperidin-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 12 h

3.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

4.1: water; tetrahydrofuran; methanol / 2 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane; water / 1 h / 20 °C

5.2: 0.17 h / 0 °C

With hydrogenchloride; hydrogen; sodium carbonate; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 1393685-65-8
8-(2,5-difluoro-4-nitrophenyl)-1,4-dioxa-spiro[4.5]dec-7-ene

: 1393685-92-1
4-[4-(4-amino-2,5-difluorophenyl)cyclohexylideneaminooxy]piperidin-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 12 h

2.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

3.1: water; tetrahydrofuran; methanol / 2 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane; water / 1 h / 20 °C

4.2: 0.17 h / 0 °C

With hydrogenchloride; hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate;