2-phenyl-3-tosyloxazolidine

Base Information

• Chemical Name: 2-phenyl-3-tosyloxazolidine
• CAS No.: 70509-21-6
• Molecular Formula: C₁₆H₁₇NO₃S
• Molecular Weight: 303.382
• Mol file: 70509-21-6.mol

Synonyms:2-phenyl-3-tosyloxazolidine

Chemical Property of 2-phenyl-3-tosyloxazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-3-tosyloxazolidine

There total 6 articles about 2-phenyl-3-tosyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C16H18FNO3S + 4-methoxyphenylacetylen (768-60-5) → 2-phenyl-3-tosyloxazolidine (70509-21-6)

Guidance literature:

With tetrakis(acetonitrile)copper(I) hexafluorophosphate; 2.9-dimethyl-1,10-phenanthroline; potassium carbonate; In dichloromethane; at 80 ℃; for 6h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/acscatal.0c03853

Reference yield: 34.0%

N-(2-(benzyloxy)ethyl)-N-chloro-4-methylbenzenesulfonamide → 2-phenyl-3-tosyloxazolidine (70509-21-6)

Guidance literature:

N-(2-(benzyloxy)ethyl)-N-chloro-4-methylbenzenesulfonamide; With disodium hydrogenphosphate; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; In acetonitrile; at 20 ℃; for 12h; Inert atmosphere; Irradiation;

With sodium hydroxide; In acetonitrile; at 20 ℃; for 4h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00582

Reference yield:

benzaldehyde dimethyl acetal (1125-88-8) + N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide (14316-14-4) → 2-phenyl-3-tosyloxazolidine (70509-21-6)

Guidance literature:

With camphor-10-sulfonic acid; In 1,2-dichloro-ethane; at 20 - 70 ℃;

DOI:10.1021/ja802896n

upstream raw materials:

2-(N-benzylidenamino)ethanol

p-toluenesulfonyl chloride

benzaldehyde dimethyl acetal

N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide