(S)-benzyl 2-((2R,6R)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-(diphenylmethyleneamino)acetate

Base Information

Chemical Name:(S)-benzyl 2-((2R,6R)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-(diphenylmethyleneamino)acetate
CAS No.:1359976-81-0
Molecular Formula:C₂₉H₃₁NO₃
Molecular Weight:441.57
Hs Code.:

Synonyms:(S)-benzyl 2-((2R,6R)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-(diphenylmethyleneamino)acetate

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Chemical Property of (S)-benzyl 2-((2R,6R)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-(diphenylmethyleneamino)acetate

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Technology Process of (S)-benzyl 2-((2R,6R)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-(diphenylmethyleneamino)acetate

There total 5 articles about (S)-benzyl 2-((2R,6R)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-(diphenylmethyleneamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1359976-77-4
(2R,6R)-2,6-dimethyltetrahydro-2H-pyran-4-yl 4-methylbenzenesulfonate

: 81477-91-0
benzyl 2-(diphenylmethyleneamino)acetate

: 1359976-81-0
(S)-benzyl 2-((2R,6R)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-(diphenylmethyleneamino)acetate

: 1359976-80-9
(R)-benzyl 2-((2R,6R)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-(diphenylmethyleneamino)acetate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at 100 ℃; for 8h; Sealed vessel; Inert atmosphere;

Reference yield:

: 14505-80-7
(+/-)-trans-2,6-dimethyltetrahydropyran-4-one

: 1359976-81-0
(S)-benzyl 2-((2R,6R)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-(diphenylmethyleneamino)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; methanol / 1.17 h / 0 - 20 °C

1.2: 2.5 h / 20 °C

2.1: Chiralpak AD-H / n-heptane; ethanol; carbon dioxide / Resolution of racemate

3.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 8 h / 100 °C / Sealed vessel; Inert atmosphere

With methanol; sodium tetrahydroborate; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; n-heptane; carbon dioxide; toluene;

Reference yield:

: rac-(2R,6R)-2,6-dimethyltetrahydro-2H-pyran-4-yl 4-methylbenzenesulfonate

: 1359976-81-0
(S)-benzyl 2-((2R,6R)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-(diphenylmethyleneamino)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: Chiralpak AD-H / n-heptane; ethanol; carbon dioxide / Resolution of racemate

2: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 8 h / 100 °C / Sealed vessel; Inert atmosphere

With lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; n-heptane; carbon dioxide; toluene;