tert-butyl 3-(3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)ureido)azetidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)ureido)azetidine-1-carboxylate
CAS No.:1429307-60-7
Molecular Formula:C₃₆H₄₃FN₆O₇S
Molecular Weight:722.838
Hs Code.:

tert-butyl 3-(3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)ureido)azetidine-1-carboxylate

Synonyms:tert-butyl 3-(3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)ureido)azetidine-1-carboxylate

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Chemical Property of tert-butyl 3-(3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)ureido)azetidine-1-carboxylate

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Technology Process of tert-butyl 3-(3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)ureido)azetidine-1-carboxylate

There total 1 articles about tert-butyl 3-(3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)ureido)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193269-78-2
3-aminoazetidine-1-carboxylic acid tert-butyl ester

: 1123837-34-2
tert-butyl {[6-[7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl]pyridin-3-yl]methyl}(2-methoxyethyl)carbamate

: 1885-14-9
phenyl chloroformate

: 1429307-60-7
tert-butyl 3-(3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)ureido)azetidine-1-carboxylate

Guidance literature:: tert-butyl {[6-[7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl]pyridin-3-yl]methyl}(2-methoxyethyl)carbamate; phenyl chloroformate; With pyridine; for 0.166667h;

3-aminoazetidine-1-carboxylic acid tert-butyl ester; at 110 ℃; for 8h; Time;

Reference yield:

: 1429307-60-7
tert-butyl 3-(3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)ureido)azetidine-1-carboxylate

: 1429307-89-0
1-(azetidin-3-yl)-3-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1.5h;

Reference yield:

: 1429307-60-7
tert-butyl 3-(3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)ureido)azetidine-1-carboxylate

: N-ethyl-3-(3-(4-(2-(5-((3-ethyl-1-(2-methoxyethyl)ureido)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)ureido)azetidine-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1.5 h

2.1: tetrahydrofuran / 0.5 h

2.2: 2 h

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;