(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((4-fluoro-N-methylphenylsulfonamido)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1.9.5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

Base Information

Chemical Name:(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((4-fluoro-N-methylphenylsulfonamido)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1.9.5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate
CAS No.:1353557-63-7
Molecular Formula:C₅₀H₅₄FN₃O₉S
Molecular Weight:892.058
Hs Code.:

(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((4-fluoro-N-methylphenylsulfonamido)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1.9.5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

Synonyms:(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((4-fluoro-N-methylphenylsulfonamido)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1.9.5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

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Chemical Property of (S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((4-fluoro-N-methylphenylsulfonamido)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1.9.5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

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Technology Process of (S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((4-fluoro-N-methylphenylsulfonamido)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1.9.5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

There total 4 articles about (S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((4-fluoro-N-methylphenylsulfonamido)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1.9.5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: C₄₄H₅₁N₃O₇

: 1353557-63-7
(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((4-fluoro-N-methylphenylsulfonamido)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1.9.5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1021/ml200244k

Reference yield:

: 1255214-08-4
allyl (((2S,8R,9R)-14-((((9H-fIuoren-9-yl)methoxy)carbonyl)amino)-11-((S)-1-hydroxypropan-2-yl)-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)(methyl)carbamate

: 1353557-63-7
(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((4-fluoro-N-methylphenylsulfonamido)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1.9.5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: 2,6-dimethylpyridine / dichloromethane / 15 h / 20 °C / Inert atmosphere

With pyridine; 2,6-dimethylpyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; In dichloromethane;
DOI:10.1021/ml200244k

Reference yield:

: 1353557-59-1
(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

: 1353557-63-7
(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((4-fluoro-N-methylphenylsulfonamido)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1.9.5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: 2,6-dimethylpyridine / dichloromethane / 15 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; In dichloromethane;
DOI:10.1021/ml200244k