Benzoic acid 12-((2R,4S,5S,6R)-4-hydroxy-5-methoxymethoxy-6-methyl-piperidin-2-yl)-dodecyl ester

Base Information

Chemical Name:Benzoic acid 12-((2R,4S,5S,6R)-4-hydroxy-5-methoxymethoxy-6-methyl-piperidin-2-yl)-dodecyl ester
CAS No.:220023-86-9
Molecular Formula:C₂₇H₄₅NO₅
Molecular Weight:463.658
Hs Code.:

Synonyms:Benzoic acid 12-((2R,4S,5S,6R)-4-hydroxy-5-methoxymethoxy-6-methyl-piperidin-2-yl)-dodecyl ester

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Chemical Property of Benzoic acid 12-((2R,4S,5S,6R)-4-hydroxy-5-methoxymethoxy-6-methyl-piperidin-2-yl)-dodecyl ester

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Technology Process of Benzoic acid 12-((2R,4S,5S,6R)-4-hydroxy-5-methoxymethoxy-6-methyl-piperidin-2-yl)-dodecyl ester

There total 8 articles about Benzoic acid 12-((2R,4S,5S,6R)-4-hydroxy-5-methoxymethoxy-6-methyl-piperidin-2-yl)-dodecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: Chloro-methanesulfonate(2R,3S,4S,6R)-6-(12-benzoyloxy-dodecyl)-1-benzyl-3-methoxymethoxy-2-methyl-7-oxa-1-azonia-bicyclo[2.2.1]heptane;

: 220023-86-9
Benzoic acid 12-((2R,4S,5S,6R)-4-hydroxy-5-methoxymethoxy-6-methyl-piperidin-2-yl)-dodecyl ester

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; for 15h; Ambient temperature;
DOI:10.1016/S0040-4020(98)01012-6

Reference yield:

: 13362-52-2
1,13-tridecanediol

: 220023-86-9
Benzoic acid 12-((2R,4S,5S,6R)-4-hydroxy-5-methoxymethoxy-6-methyl-piperidin-2-yl)-dodecyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 54 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

2: PCC, AcONa / CH₂Cl₂ / 2 h / Ambient temperature

3: 48 percent / 4 Angstroem MS / toluene / 2 h / Ambient temperature

4: 31 percent / toluene / 48 h

5: 82 percent / DIPEA / CH₂Cl₂ / 30 h / Heating

6: pyridine / 2 h / 0 °C

7: 77 percent / H₂ / Pd(OH)2/C / methanol / 15 h / Ambient temperature

With 4 Angstroem MS; hydrogen; sodium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; palladium dihydroxide; In pyridine; methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(98)01012-6

Reference yield:

: 98-88-4
benzoyl chloride

: 220023-86-9
Benzoic acid 12-((2R,4S,5S,6R)-4-hydroxy-5-methoxymethoxy-6-methyl-piperidin-2-yl)-dodecyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 54 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

2: PCC, AcONa / CH₂Cl₂ / 2 h / Ambient temperature

3: 48 percent / 4 Angstroem MS / toluene / 2 h / Ambient temperature

4: 31 percent / toluene / 48 h

5: 82 percent / DIPEA / CH₂Cl₂ / 30 h / Heating

6: pyridine / 2 h / 0 °C

7: 77 percent / H₂ / Pd(OH)2/C / methanol / 15 h / Ambient temperature

With 4 Angstroem MS; hydrogen; sodium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; palladium dihydroxide; In pyridine; methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(98)01012-6