methyl 5-((3aS,4S,6aR)-3-benzyl-1-(bis(4-methoxyphenyl)-(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

Base Information

Chemical Name:methyl 5-((3aS,4S,6aR)-3-benzyl-1-(bis(4-methoxyphenyl)-(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate
CAS No.:1340499-01-5
Molecular Formula:C₃₉H₄₂N₂O₅S
Molecular Weight:650.839
Hs Code.:

Synonyms:methyl 5-((3aS,4S,6aR)-3-benzyl-1-(bis(4-methoxyphenyl)-(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

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Chemical Property of methyl 5-((3aS,4S,6aR)-3-benzyl-1-(bis(4-methoxyphenyl)-(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

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Technology Process of methyl 5-((3aS,4S,6aR)-3-benzyl-1-(bis(4-methoxyphenyl)-(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

There total 3 articles about methyl 5-((3aS,4S,6aR)-3-benzyl-1-(bis(4-methoxyphenyl)-(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 100-39-0
benzyl bromide

: 122224-36-6
1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester

: 1340499-01-5
methyl 5-((3aS,4S,6aR)-3-benzyl-1-(bis(4-methoxyphenyl)-(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

Guidance literature:: 1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h; Inert atmosphere; Cooling with ice;

benzyl bromide; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; regioselective reaction; Cooling with ice; Inert atmosphere;
DOI:10.1021/jo201615j

Reference yield:

: 58-85-5,22879-79-4
biotin

: 1340499-01-5
methyl 5-((3aS,4S,6aR)-3-benzyl-1-(bis(4-methoxyphenyl)-(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride

2.1: pyridine; dmap; triethylamine / 4 h / 75 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere; Cooling with ice

3.2: 20 °C / Cooling with ice; Inert atmosphere

With pyridine; dmap; thionyl chloride; sodium hydride; triethylamine; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo201615j

Reference yield:

: 608-16-2
biotin methyl ester

: 1340499-01-5
methyl 5-((3aS,4S,6aR)-3-benzyl-1-(bis(4-methoxyphenyl)-(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; dmap; triethylamine / 4 h / 75 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere; Cooling with ice

2.2: 20 °C / Cooling with ice; Inert atmosphere

With pyridine; dmap; sodium hydride; triethylamine; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo201615j