2(S)-amino-3(R)-[2(S)-(3-benzoyl-phenyl)-propionyloxy]-butyric acid hydrochloride

Base Information

Chemical Name:2(S)-amino-3(R)-[2(S)-(3-benzoyl-phenyl)-propionyloxy]-butyric acid hydrochloride
CAS No.:852055-85-7
Molecular Formula:C₂₀H₂₁NO₅*ClH
Molecular Weight:391.851
Hs Code.:

Synonyms:2(S)-amino-3(R)-[2(S)-(3-benzoyl-phenyl)-propionyloxy]-butyric acid hydrochloride

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Chemical Property of 2(S)-amino-3(R)-[2(S)-(3-benzoyl-phenyl)-propionyloxy]-butyric acid hydrochloride

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Technology Process of 2(S)-amino-3(R)-[2(S)-(3-benzoyl-phenyl)-propionyloxy]-butyric acid hydrochloride

There total 4 articles about 2(S)-amino-3(R)-[2(S)-(3-benzoyl-phenyl)-propionyloxy]-butyric acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 852055-86-8
3-[2(S)-(3-benzoyl-phenyl)-propionyloxy]-2(S)-tert-butoxycarbonylamino-butyric acid tert-butyl ester

: 852055-85-7
2(S)-amino-3(R)-[2(S)-(3-benzoyl-phenyl)-propionyloxy]-butyric acid hydrochloride

Guidance literature:: 3-[2(S)-(3-benzoyl-phenyl)-propionyloxy]-2(S)-tert-butoxycarbonylamino-butyric acid tert-butyl ester; With hydrogenchloride; In diethyl ether; at 20 ℃; for 17h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6.5h;

With hydrogenchloride; In diethyl ether; ethanol; at 20 ℃; for 2h;

Reference yield:

: (+/-)-ketoprofen-L-threonine ester hydrochloride

: 852055-85-7
2(S)-amino-3(R)-[2(S)-(3-benzoyl-phenyl)-propionyloxy]-butyric acid hydrochloride

Guidance literature:: In acetonitrile;

Reference yield:

: 22071-15-4,22161-86-0
ketoprofen

: 852055-85-7
2(S)-amino-3(R)-[2(S)-(3-benzoyl-phenyl)-propionyloxy]-butyric acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C

2.1: hydrogenchloride / dichloromethane / 17 h / 20 °C

2.2: 6.5 h / 20 °C

2.3: 2 h / 20 °C

3.1: acetonitrile

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile;