Technology Process of (S,E)-2-((1,3-diphenylallyl)oxy)-2,3-dihydro-1H-indene
There total 5 articles about (S,E)-2-((1,3-diphenylallyl)oxy)-2,3-dihydro-1H-indene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis(η3-allyl-μ-chloropalladium(II)); (S)-2′-(tert-butyl)-7-(diphenylphosphino)-2,3-dihydro-5′H-spiro[indene-1,4′-oxazole]; caesium carbonate;
In
dichloromethane;
at 0 - 25 ℃;
for 5h;
enantioselective reaction;
Schlenk technique;
Inert atmosphere;
DOI:10.3390/molecules24081575
- Guidance literature:
-
With
caesium carbonate;
bis(η3-allyl-μ-chloropalladium(II)); chiral ferrocene-based catalyst;
In
toluene;
at 20 ℃;
for 3h;
Title compound not separated from byproducts.;
DOI:10.1002/anie.200703955
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydroxide / ethanol; water / 0 - 20 °C
2: sodium tetrahydroborate / methanol / 5 h / 0 - 20 °C
3: triethylamine; dmap / dichloromethane / 24 h / 20 °C
4: caesium carbonate; di-μ-chlorido-bis(η3-1,3-diphenylallyl)dipalladium(II); (R)-7-(bis(3,5-di-tert-butylphenyl)phosphino)spiro[indane-1,2′-pyrrolidine] / toluene / 18 h / 20 °C / Schlenk technique; Inert atmosphere
With
dmap; sodium tetrahydroborate; di-μ-chlorido-bis(η3-1,3-diphenylallyl)dipalladium(II); (R)-7-(bis(3,5-di-tert-butylphenyl)phosphino)spiro[indane-1,2′-pyrrolidine]; caesium carbonate; triethylamine; sodium hydroxide;
In
methanol; ethanol; dichloromethane; water; toluene;
DOI:10.1021/acs.joc.9b00875