4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid methyl ester
• CAS No.: 883969-07-1
• Molecular Formula: C₂₅H₂₆Cl₂N₂O₆S
• Molecular Weight: 553.463
• Mol file: 883969-07-1.mol

Synonyms:4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid methyl ester

Chemical Property of 4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid methyl ester

There total 2 articles about 4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-(3-bromomethyl-2,4-dichloro-benzenesulfonylamino)-tetrahydro-pyran-4-carboxylic acid methyl ester (883969-06-0) + 8-hydroxy-2,4-dimethylquinoline (115310-98-0) → 4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid methyl ester (883969-07-1)

Guidance literature:

8-hydroxy-2,4-dimethylquinoline; With lithium hydroxide; In butanone; at 20 ℃; for 1.5h;

4-(3-bromomethyl-2,4-dichloro-benzenesulfonylamino)-tetrahydro-pyran-4-carboxylic acid methyl ester; In N,N-dimethyl-formamide; butanone; for 16h;

Reference yield:

3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride (188440-21-3) + tetrabutyl-ammonium; 2,4-dimethyl-quinolin-8-olate + 4-amino-tetrahydropyran-4-carboxylic acid methyl ester hydrochloride → 4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid methyl ester (883969-07-1)

Guidance literature:

3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride; 4-amino-tetrahydropyran-4-carboxylic acid methyl ester hydrochloride; With sodium hydrogencarbonate; In acetonitrile; at 5 ℃; for 19.5h;

tetrabutyl-ammonium; 2,4-dimethyl-quinolin-8-olate; With tetrabutylammomium bromide; In acetonitrile; for 24h; Heating;

DOI:10.1021/jm061143k

Reference yield: 90.0%

4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid methyl ester (883969-07-1) → 4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid (883969-08-2)

Guidance literature:

4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid methyl ester; With lithium hydroxide; water; In tetrahydrofuran; at 40 ℃; for 4h;

With hydrogenchloride; water; In ethyl acetate;

upstream raw materials:

3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride

4-(3-bromomethyl-2,4-dichloro-benzenesulfonylamino)-tetrahydro-pyran-4-carboxylic acid methyl ester

8-hydroxy-2,4-dimethylquinoline

Downstream raw materials:

4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid

2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-pyran-4-yl]-benzenesufonamide

tert-butyl 4-(4-[2,4-dichloro-3-(2,4-dimethylquinolin-8-yloxymethyl)benzenesulfonylamino]tetrahydropyran-4-ylcarbonyl)piperazine-1-carboxylate

[4-tert-butoxycarbonylamino-5-(4-{4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl}-piperazin-1-yl)-5-oxo-pentyl]-trimethyl-ammonium