5-(benzyloxy)-2-((2-(7-chloroquinolin-4-ylamino)ethylamino)methyl)-1-cyclopropylpyridin-4(1H)-one

Base Information

Chemical Name:5-(benzyloxy)-2-((2-(7-chloroquinolin-4-ylamino)ethylamino)methyl)-1-cyclopropylpyridin-4(1H)-one
CAS No.:1620023-77-9
Molecular Formula:C₂₇H₂₇ClN₄O₂
Molecular Weight:474.99
Hs Code.:

Synonyms:5-(benzyloxy)-2-((2-(7-chloroquinolin-4-ylamino)ethylamino)methyl)-1-cyclopropylpyridin-4(1H)-one

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Chemical Property of 5-(benzyloxy)-2-((2-(7-chloroquinolin-4-ylamino)ethylamino)methyl)-1-cyclopropylpyridin-4(1H)-one

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Technology Process of 5-(benzyloxy)-2-((2-(7-chloroquinolin-4-ylamino)ethylamino)methyl)-1-cyclopropylpyridin-4(1H)-one

There total 6 articles about 5-(benzyloxy)-2-((2-(7-chloroquinolin-4-ylamino)ethylamino)methyl)-1-cyclopropylpyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 5407-57-8
N-(7-chloroquinolin-4-yl)ethylenediamine

: 5-(benzyloxy)-2-(chloromethyl)-1-cyclopropylpyridin-(1H)-one hydrogen chloride

: 1620023-77-9
5-(benzyloxy)-2-((2-(7-chloroquinolin-4-ylamino)ethylamino)methyl)-1-cyclopropylpyridin-4(1H)-one

Guidance literature:: With sodium hydrogencarbonate; triethylamine; In N,N-dimethyl-formamide; at 110 ℃; for 24h;
DOI:10.1016/j.bmcl.2014.06.012

Reference yield:

: 501-30-4,123712-78-7
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 1620023-77-9
5-(benzyloxy)-2-((2-(7-chloroquinolin-4-ylamino)ethylamino)methyl)-1-cyclopropylpyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / methanol / 12 h / 80 - 84 °C

2: water; ethanol / 12 h / 70 °C / Sealed tube

3: thionyl chloride / 1 h / -7 - 20 °C

4: triethylamine; sodium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 110 °C

With thionyl chloride; sodium hydrogencarbonate; triethylamine; sodium hydroxide; In methanol; ethanol; water; N,N-dimethyl-formamide; 2: |Michael Addition;
DOI:10.1016/j.bmcl.2014.06.012

Reference yield:

: 15771-06-9
5-benzyloxy-2-hydroxymethyl-4H-pyran-4-one

: 1620023-77-9
5-(benzyloxy)-2-((2-(7-chloroquinolin-4-ylamino)ethylamino)methyl)-1-cyclopropylpyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: water; ethanol / 12 h / 70 °C / Sealed tube

2: thionyl chloride / 1 h / -7 - 20 °C

3: triethylamine; sodium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 110 °C

With thionyl chloride; sodium hydrogencarbonate; triethylamine; In ethanol; water; N,N-dimethyl-formamide; 1: |Michael Addition;
DOI:10.1016/j.bmcl.2014.06.012