tert-butyl 2-((S)-2-(2-((S)-2-(methylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamate

Base Information

Chemical Name:tert-butyl 2-((S)-2-(2-((S)-2-(methylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamate
CAS No.:1374822-19-1
Molecular Formula:C₃₂H₄₁N₅O₆
Molecular Weight:591.707
Hs Code.:

Synonyms:tert-butyl 2-((S)-2-(2-((S)-2-(methylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamate

Suppliers and Price of tert-butyl 2-((S)-2-(2-((S)-2-(methylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 2-((S)-2-(2-((S)-2-(methylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 2-((S)-2-(2-((S)-2-(methylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamate

There total 9 articles about tert-butyl 2-((S)-2-(2-((S)-2-(methylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1374822-18-0
(S)-methyl 1-(2-(((S)-1-(2-((tert-butoxycarbonylamino)methyl)benzoyl)pyrrolidine-2-carboxamido)methyl)benzoyl)pyrrolidine-2-carboxylate

: 74-89-5
methylamine

: 1374822-19-1
tert-butyl 2-((S)-2-(2-((S)-2-(methylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamate

Guidance literature:: In methanol; at 20 ℃; for 6h; Saturated solution;
DOI:10.1016/j.tet.2012.02.006

Reference yield:

: 1374822-13-5
(S)-methyl 1-(2-(azidomethyl)benzoyl)pyrrolidine-2-carboxylate

: 1374822-19-1
tert-butyl 2-((S)-2-(2-((S)-2-(methylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen; triethylamine / ethyl acetate / 5 h / 20 °C / 3102.97 Torr

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Cooling with ice

4: methanol / 6 h / 20 °C / Saturated solution

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.tet.2012.02.006

Reference yield:

: 89-71-4
2-Methyl-benzoic acid methyl ester

: 1374822-19-1
tert-butyl 2-((S)-2-(2-((S)-2-(methylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamoyl)pyrrolidine-1-carbonyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 9 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 1 h / Reflux

2: sodium azide / methanol / 24 h / Reflux

3: sodium hydroxide / methanol / 0.5 h / 20 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

5: triethylamine / dichloromethane / 20 °C / Cooling with ice

6: palladium 10% on activated carbon; hydrogen; triethylamine / ethyl acetate / 5 h / 20 °C / 3102.97 Torr

7: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Cooling with ice

9: methanol / 6 h / 20 °C / Saturated solution

With N-Bromosuccinimide; sodium azide; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; dibenzoyl peroxide; In methanol; tetrachloromethane; dichloromethane; ethyl acetate;
DOI:10.1016/j.tet.2012.02.006