(3R,5R)-methyl 3-(benzylthio-methyl)-3-methyl-2-oxo-5-phenylmorpholine-4-carboxylate

Base Information

Chemical Name:(3R,5R)-methyl 3-(benzylthio-methyl)-3-methyl-2-oxo-5-phenylmorpholine-4-carboxylate
CAS No.:1367363-42-5
Molecular Formula:C₂₁H₂₃NO₄S
Molecular Weight:385.484
Hs Code.:

Synonyms:(3R,5R)-methyl 3-(benzylthio-methyl)-3-methyl-2-oxo-5-phenylmorpholine-4-carboxylate

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Chemical Property of (3R,5R)-methyl 3-(benzylthio-methyl)-3-methyl-2-oxo-5-phenylmorpholine-4-carboxylate

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Technology Process of (3R,5R)-methyl 3-(benzylthio-methyl)-3-methyl-2-oxo-5-phenylmorpholine-4-carboxylate

There total 2 articles about (3R,5R)-methyl 3-(benzylthio-methyl)-3-methyl-2-oxo-5-phenylmorpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 950672-64-7
(3R,5R)-3-((benzylthio)methyl)-3-methyl-5-phenylmorpholin-2-one

: 79-22-1
methyl chloroformate

: 1367363-42-5
(3R,5R)-methyl 3-(benzylthio-methyl)-3-methyl-2-oxo-5-phenylmorpholine-4-carboxylate

Guidance literature:: (3R,5R)-3-((benzylthio)methyl)-3-methyl-5-phenylmorpholin-2-one; With lithium hydride; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

methyl chloroformate; In tetrahydrofuran; at 40 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.02.008

Reference yield:

: 950672-60-3
(R)-2-benzylsulfanylmethyl-2-methyl-4-phenyl-oxazolidine

: 1367363-42-5
(3R,5R)-methyl 3-(benzylthio-methyl)-3-methyl-2-oxo-5-phenylmorpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium bromide ethyl etherate / toluene / 18 h / -40 °C / Inert atmosphere

2.1: hydrogenchloride / dichloromethane / 0.25 h / -20 °C / Inert atmosphere

2.2: 12 h / -20 - 20 °C / Inert atmosphere

2.3: 0.5 h / Inert atmosphere

3.1: lithium hydride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

3.2: 48 h / 40 °C / Inert atmosphere

With hydrogenchloride; lithium hydride; magnesium bromide ethyl etherate; In tetrahydrofuran; dichloromethane; toluene; 1.1: Strecker reaction;
DOI:10.1016/j.tetlet.2012.02.008