methyl (4-{3-[4-(1-aminocyclobutyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl}phenyl)acetate

Base Information

Chemical Name:methyl (4-{3-[4-(1-aminocyclobutyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl}phenyl)acetate
CAS No.:1374261-23-0
Molecular Formula:C₃₃H₂₉N₅O₂
Molecular Weight:527.626
Hs Code.:

Synonyms:methyl (4-{3-[4-(1-aminocyclobutyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl}phenyl)acetate

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Chemical Property of methyl (4-{3-[4-(1-aminocyclobutyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl}phenyl)acetate

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Technology Process of methyl (4-{3-[4-(1-aminocyclobutyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl}phenyl)acetate

There total 7 articles about methyl (4-{3-[4-(1-aminocyclobutyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl}phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1374260-87-3
tert-butyl {1-[4-(2-bromo-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

: 454185-96-7
[4-(2-methoxy-2-oxoethyl)phenyl]boronic acid

: 1374261-23-0
methyl (4-{3-[4-(1-aminocyclobutyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl}phenyl)acetate

Guidance literature:: tert-butyl {1-[4-(2-bromo-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate; [4-(2-methoxy-2-oxoethyl)phenyl]boronic acid; With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In methanol; water; N,N-dimethyl-formamide; at 160 ℃; for 1h; Microwave irradiation;

With hydrogenchloride; In methanol; water; for 24h;

Reference yield:

: 1374260-84-0
tert-butyl {1-[4-(9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

: 1374261-23-0
methyl (4-{3-[4-(1-aminocyclobutyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl}phenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridinium perbromide hydrobromide / tetrahydrofuran / -78 - 20 °C

2.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / methanol; water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

2.2: 24 h

With potassium phosphate; pyridinium perbromide hydrobromide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 885-70-1
5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

: 1374261-23-0
methyl (4-{3-[4-(1-aminocyclobutyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl}phenyl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: Lawessons reagent; pyridine / 18 h / 100 °C

2.1: 1 h / 95 °C

3.1: acetic acid / 13 h / 105 °C

4.1: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

6.1: pyridinium perbromide hydrobromide / tetrahydrofuran / -78 - 20 °C

7.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / methanol; water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

7.2: 24 h

With Lawessons reagent; pyridine; potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridinium perbromide hydrobromide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;