tert-butyl {1-[4-(9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

Base Information

• Chemical Name: tert-butyl {1-[4-(9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate
• CAS No.: 1374260-84-0
• Molecular Formula: C₂₉H₂₉N₅O₂
• Molecular Weight: 479.582
• Mol file: 1374260-84-0.mol

Synonyms:tert-butyl {1-[4-(9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

Chemical Property of tert-butyl {1-[4-(9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl {1-[4-(9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

There total 5 articles about tert-butyl {1-[4-(9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester (1032528-06-5) + 3-bromo-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepine (1374260-83-9) → tert-butyl {1-[4-(9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate (1374260-84-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In ethanol; water; toluene; for 15h; Reflux;

Reference yield:

5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one (885-70-1) → tert-butyl {1-[4-(9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate (1374260-84-0)

Guidance literature:

Multi-step reaction with 5 steps

1: Lawessons reagent; pyridine / 18 h / 100 °C

2: 1 h / 95 °C

3: acetic acid / 13 h / 105 °C

4: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

With Lawessons reagent; pyridine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; ethanol; water; toluene;

Reference yield:

5,11-dihydro-6H-pyrido[2,3-b][1,4]benzo diazepine-6-thione (1204296-84-3) → tert-butyl {1-[4-(9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate (1374260-84-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1 h / 95 °C

2: acetic acid / 13 h / 105 °C

3: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; ethanol; water; toluene;

upstream raw materials:

{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

3-bromo-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepine

5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

5,11-dihydro-6H-pyrido[2,3-b][1,4]benzo diazepine-6-thione

Downstream raw materials:

1-{4-[2-(1H-pyrrolo[3,2-b]pyridin-6-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine

tert-butyl [1-(4-{2-[4-(2-oxopiperidin-1-yl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate

tert-butyl [1-(4-{2-[6-(4-methoxyphenyl)pyridin-3-yl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate

tert-butyl [1-(4-{2-[4-(benzyloxy)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate