1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-methylurea

Base Information

• Chemical Name: 1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-methylurea
• CAS No.: 1452129-10-0
• Molecular Formula: C₁₉H₂₂N₆O₃
• Molecular Weight: 382.422
• Mol file: 1452129-10-0.mol

Synonyms:1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-methylurea

Chemical Property of 1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-methylurea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-methylurea

There total 6 articles about 1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H17N5O3 + methylamine (74-89-5) → 1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-methylurea (1452129-10-0)

Guidance literature:

In tetrahydrofuran; ethanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-0033-1338482

Reference yield:

6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-amine (1452129-04-2) → 1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-methylurea (1452129-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran; ethanol / 0 - 20 °C / Inert atmosphere

With bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol;

DOI:10.1055/s-0033-1338482

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-methylurea (1452129-10-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere

2: bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: tetrahydrofuran; ethanol / 0 - 20 °C / Inert atmosphere

With bis(trichloromethyl) carbonate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol;

DOI:10.1055/s-0033-1338482

upstream raw materials:

6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-amine

benzyl alcohol

2-acetoxytetrahydropyran

methylamine