4-Methanesulfinyl-6-(4-methoxy-phenyl)-2-oxo-2H-pyran-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 4-Methanesulfinyl-6-(4-methoxy-phenyl)-2-oxo-2H-pyran-3-carboxylic acid methyl ester
• CAS No.: 115411-61-5
• Molecular Formula: C₁₅H₁₄O₆S
• Molecular Weight: 322.339
• Mol file: 115411-61-5.mol

Synonyms:4-Methanesulfinyl-6-(4-methoxy-phenyl)-2-oxo-2H-pyran-3-carboxylic acid methyl ester

Chemical Property of 4-Methanesulfinyl-6-(4-methoxy-phenyl)-2-oxo-2H-pyran-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-Methanesulfinyl-6-(4-methoxy-phenyl)-2-oxo-2H-pyran-3-carboxylic acid methyl ester

There total 4 articles about 4-Methanesulfinyl-6-(4-methoxy-phenyl)-2-oxo-2H-pyran-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 6-(4-methoxyphenyl)-4-(methylthio)-2-oxo-2H-pyran-3-carboxylate (61380-88-9) → 4-Methanesulfinyl-6-(4-methoxy-phenyl)-2-oxo-2H-pyran-3-carboxylic acid methyl ester (115411-61-5)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 3h; Ambient temperature;

Reference yield: 78.0%

methyl 6-(4-methoxyphenyl)-4-(methylthio)-2-oxo-2H-pyran-3-carboxylate (61380-88-9) → methyl 4-hydroxy-6-(p-methoxyphenyl)-2-oxo-2H-pyran-3-carboxylate (115411-66-0) + 4-Methanesulfinyl-6-(4-methoxy-phenyl)-2-oxo-2H-pyran-3-carboxylic acid methyl ester (115411-61-5)

Guidance literature:

With dihydrogen peroxide; In acetic acid; at 40 - 50 ℃; for 1h;

Reference yield:

methyl 2-methoxycarbonyl-3,3-di(methylsulfanyl)acrylate (19607-08-0) → 4-Methanesulfinyl-6-(4-methoxy-phenyl)-2-oxo-2H-pyran-3-carboxylic acid methyl ester (115411-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 39 percent / KOH (s) / dimethylsulfoxide / Ambient temperature

2: 78 percent / 30percent aq. H₂O₂ / acetic acid / 1 h / 40 - 50 °C

With potassium hydroxide; dihydrogen peroxide; In acetic acid; dimethyl sulfoxide;

upstream raw materials:

methyl 6-(4-methoxyphenyl)-4-(methylthio)-2-oxo-2H-pyran-3-carboxylate

methyl 2-methoxycarbonyl-3,3-di(methylsulfanyl)acrylate

1-(4-methoxyphenyl)ethanone

Downstream raw materials:

2-(p-methoxyphenyl)pyrano<3,4-d>pyrido<1,2-a>pyrimidine-4,5(4H,5H)-dione

diethyl 3-methoxycarbonyl-6-(4-methoxyphenyl)-2-oxo-2H-pyran-4-ylmalonate

dimethyl 3-methoxycarbonyl-6-(4-methoxyphenyl)-2-oxo-2H-pyran-4-ylmalonate

4-(Cyano-methoxycarbonyl-methyl)-6-(4-methoxy-phenyl)-2-oxo-2H-pyran-3-carboxylic acid methyl ester