Methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate

Base Information

Chemical Name:Methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate
CAS No.:1339879-91-2
Molecular Formula:C₂₀H₂₀N₂O₆
Molecular Weight:384.389
Hs Code.:
Mol file:1339879-91-2.mol

Synonyms:(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido [1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid

Suppliers and Price of Methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 7 raw suppliers

Chemical Property of Methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (4R,12aS)-7-(Benzyloxy)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1'',2'':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic Acid is an antiviral agent and a Dolutegravir (D528800) intermediate. Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor.

Technology Process of Methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate

There total 13 articles about Methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1357289-04-3
(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid ethyl ester

: 1339879-91-2
(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido [1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid

Guidance literature:: (4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid ethyl ester; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=2.5;

Reference yield:

: 1339879-88-7
C₃₂H₃₃F₂N₃O₇

: 1339879-91-2
(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido [1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid

Guidance literature:: C₃₂H₃₃F₂N₃O₇; With sodium hydroxide; In ethanol; acetonitrile; at 60 ℃; for 5h;

With hydrogenchloride; In water;

Reference yield:

: 727382-68-5
4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester

: 1339879-91-2
(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido [1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 2 h / -78 °C

1.2: 1.5 h / 65 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 - 100 °C

3.1: formic acid; sulfuric acid / 3 h / 20 °C

4.1: acetic acid / methanol; toluene / 3 h / Reflux

5.1: sodium hydroxide; water / methanol; tetrahydrofuran / 2 h / 20 °C

5.2: pH 2.5

With formic acid; sulfuric acid; water; caesium carbonate; acetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;