(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid ethyl ester

Base Information

Chemical Name:(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid ethyl ester
CAS No.:1357289-04-3
Molecular Formula:C₂₂H₂₄N₂O₆
Molecular Weight:412.442
Hs Code.:

Synonyms:(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% HPLC ^*data from raw suppliers

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Technology Process of (4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid ethyl ester

There total 12 articles about (4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 61477-40-5
(R)-3-amino-1-butanol

: 1246616-87-4
C₂₀H₂₁NO₇

: 1357289-04-3
(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid ethyl ester

Guidance literature:: With acetic acid; In methanol; toluene; for 3h; Reflux;

Reference yield:

: 61477-40-5
(R)-3-amino-1-butanol

: 1,4-dihydro-4-oxo-1-(2-oxoethyl)-3-(phenylmethoxy)-2,5-pyridinedicarboxylic acid 5-ethyl ester 2-methyl ester

: 1357289-04-3
(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid ethyl ester

Guidance literature:: (R)-3-amino-1-butanol; 1,4-dihydro-4-oxo-1-(2-oxoethyl)-3-(phenylmethoxy)-2,5-pyridinedicarboxylic acid 5-ethyl ester 2-methyl ester; In methanol; toluene;

With acetic acid; Reflux;

Reference yield:

: 727382-68-5
4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester

: 1357289-04-3
(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 2 h / -78 °C

1.2: 1.5 h / 65 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 - 100 °C

3.1: formic acid; sulfuric acid / 3 h / 20 °C

4.1: acetic acid / methanol; toluene / 3 h / Reflux

With formic acid; sulfuric acid; caesium carbonate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;