(2R,3S)-2-[(R)-1-(3-Fluoro-5-trifluoromethyl-phenyl)-ethoxy]-3-phenyl-morpholine

Base Information

Chemical Name:(2R,3S)-2-[(R)-1-(3-Fluoro-5-trifluoromethyl-phenyl)-ethoxy]-3-phenyl-morpholine
CAS No.:170729-83-6
Molecular Formula:C₁₉H₁₉F₄NO₂
Molecular Weight:369.359
Hs Code.:

Synonyms:(2R,3S)-2-[(R)-1-(3-Fluoro-5-trifluoromethyl-phenyl)-ethoxy]-3-phenyl-morpholine

Suppliers and Price of (2R,3S)-2-[(R)-1-(3-Fluoro-5-trifluoromethyl-phenyl)-ethoxy]-3-phenyl-morpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-2-[(R)-1-(3-Fluoro-5-trifluoromethyl-phenyl)-ethoxy]-3-phenyl-morpholine

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3S)-2-[(R)-1-(3-Fluoro-5-trifluoromethyl-phenyl)-ethoxy]-3-phenyl-morpholine

There total 4 articles about (2R,3S)-2-[(R)-1-(3-Fluoro-5-trifluoromethyl-phenyl)-ethoxy]-3-phenyl-morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 171243-05-3
(2R,3S)-4-Benzyl-2-[1-(3-fluoro-5-trifluoromethyl-phenyl)-vinyloxy]-3-phenyl-morpholine

: 170729-83-6
(2R,3S)-2-[(R)-1-(3-Fluoro-5-trifluoromethyl-phenyl)-ethoxy]-3-phenyl-morpholine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; isopropyl alcohol; for 48h;
DOI:10.1021/jm980299k

Reference yield:

: 159706-35-1
(S)-4-benzyl-3-phenylmorpholin-2-one

: 170729-83-6
(2R,3S)-2-[(R)-1-(3-Fluoro-5-trifluoromethyl-phenyl)-ethoxy]-3-phenyl-morpholine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) L-Selectride / 1.) THF, -78 deg C, 45 min, 2.) THF, -78 deg C, 30 min

2: tetrahydrofuran; toluene / 18 h / Heating

3: H₂ / 10percent Pd/C / ethyl acetate; propan-2-ol / 48 h

With hydrogen; L-Selectride; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; isopropyl alcohol; toluene;
DOI:10.1021/jm980299k

Reference yield:

: 171243-30-4
3-fluoro-5-trifluoromethylbenzoyl chloride

: 170729-83-6
(2R,3S)-2-[(R)-1-(3-Fluoro-5-trifluoromethyl-phenyl)-ethoxy]-3-phenyl-morpholine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) L-Selectride / 1.) THF, -78 deg C, 45 min, 2.) THF, -78 deg C, 30 min

2: tetrahydrofuran; toluene / 18 h / Heating

3: H₂ / 10percent Pd/C / ethyl acetate; propan-2-ol / 48 h

With hydrogen; L-Selectride; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; isopropyl alcohol; toluene;
DOI:10.1021/jm980299k