(2R,3S)-4-Benzyl-2-[1-(3-fluoro-5-trifluoromethyl-phenyl)-vinyloxy]-3-phenyl-morpholine

Base Information

• Chemical Name: (2R,3S)-4-Benzyl-2-[1-(3-fluoro-5-trifluoromethyl-phenyl)-vinyloxy]-3-phenyl-morpholine
• CAS No.: 171243-05-3
• Molecular Formula: C₂₆H₂₃F₄NO₂
• Molecular Weight: 457.468

Synonyms:(2R,3S)-4-Benzyl-2-[1-(3-fluoro-5-trifluoromethyl-phenyl)-vinyloxy]-3-phenyl-morpholine

Chemical Property of (2R,3S)-4-Benzyl-2-[1-(3-fluoro-5-trifluoromethyl-phenyl)-vinyloxy]-3-phenyl-morpholine

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3S)-4-Benzyl-2-[1-(3-fluoro-5-trifluoromethyl-phenyl)-vinyloxy]-3-phenyl-morpholine

There total 2 articles about (2R,3S)-4-Benzyl-2-[1-(3-fluoro-5-trifluoromethyl-phenyl)-vinyloxy]-3-phenyl-morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-benzyl-3-phenylmorpholin-2-one (159706-35-1) → (2R,3S)-4-Benzyl-2-[1-(3-fluoro-5-trifluoromethyl-phenyl)-vinyloxy]-3-phenyl-morpholine (171243-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) L-Selectride / 1.) THF, -78 deg C, 45 min, 2.) THF, -78 deg C, 30 min

2: tetrahydrofuran; toluene / 18 h / Heating

With L-Selectride; In tetrahydrofuran; toluene;

DOI:10.1021/jm980299k

Reference yield:

3-fluoro-5-trifluoromethylbenzoyl chloride (171243-30-4) → (2R,3S)-4-Benzyl-2-[1-(3-fluoro-5-trifluoromethyl-phenyl)-vinyloxy]-3-phenyl-morpholine (171243-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) L-Selectride / 1.) THF, -78 deg C, 45 min, 2.) THF, -78 deg C, 30 min

2: tetrahydrofuran; toluene / 18 h / Heating

With L-Selectride; In tetrahydrofuran; toluene;

DOI:10.1021/jm980299k

Reference yield:

(2R,3S)-4-Benzyl-2-[1-(3-fluoro-5-trifluoromethyl-phenyl)-vinyloxy]-3-phenyl-morpholine (171243-05-3) → (2R,3S)-2-[(R)-1-(3-Fluoro-5-trifluoromethyl-phenyl)-ethoxy]-3-phenyl-morpholine (170729-83-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; isopropyl alcohol; for 48h;

DOI:10.1021/jm980299k

upstream raw materials:

(S)-4-benzyl-3-phenylmorpholin-2-one

3-fluoro-5-trifluoromethylbenzoyl chloride

Downstream raw materials:

(2R,3S)-2-[(R)-1-(3-Fluoro-5-trifluoromethyl-phenyl)-ethoxy]-3-phenyl-morpholine

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