3-Amino-5-(4-fluorophenyl)-4-(4-pyridyl)pyrazole

Base Information

Chemical Name:3-Amino-5-(4-fluorophenyl)-4-(4-pyridyl)pyrazole
CAS No.:148671-44-7
Molecular Formula:C₁₄H₁₁FN₄
Molecular Weight:254.267
Hs Code.:
ChEMBL ID:CHEMBL3310127
DSSTox Substance ID:DTXSID401215727

Synonyms:CHEMBL3310127;3-amino-5-(4-fluorophenyl)-4-(4-pyridyl)pyrazole;SCHEMBL6177789;RVZNYFIJKBEGRZ-UHFFFAOYSA-N;DTXSID401215727;BDBM50046032;AKOS017581158;148671-44-7;5-amino-3-(4-fluorophenyl)-4-(4-pyridyl)pyrazole;5-amino-3-(4-fluorophenyl)-4-(pyridin-4-yl)pyrazole;5-amino-3-(4-fluorophenyl)-4-(pyridin-4yl)pyrazole;5-amino-3-(4-fluorophenyl)-4-(pyridin4-yl)pyrazole;5-(4-Fluorophenyl)-4-(4-pyridinyl)-1H-pyrazol-3-amine

Suppliers and Price of 3-Amino-5-(4-fluorophenyl)-4-(4-pyridyl)pyrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Amino-5-(4-fluorophenyl)-4-(4-pyridyl)pyrazole

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:254.09677453
Heavy Atom Count:19
Complexity:287

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=C(C(=NN2)N)C3=CC=NC=C3)F

Technology Process of 3-Amino-5-(4-fluorophenyl)-4-(4-pyridyl)pyrazole

There total 4 articles about 3-Amino-5-(4-fluorophenyl)-4-(4-pyridyl)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 148671-42-5
3-(4-fluorophenyl)-3-oxo-2-(pyridin-4-yl)propanenitrile

: 148671-44-7
3-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-5-amine

Guidance literature:: 3-(4-fluorophenyl)-3-oxo-2-(pyridin-4-yl)propanenitrile; With trichlorophosphate; at 100 ℃; for 1h;

With hydrazine hydrate; for 3.5h; Reflux;
DOI:10.1016/j.bmc.2014.05.045

Reference yield:

: (Z)-3-chloro-3-(4-fluorophenyl)-2-(pyridin-4-yl)acrylonitrile

: 148671-44-7
3-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-5-amine

Guidance literature:: With hydrazine hydrate; In ethanol; at 100 ℃;

Reference yield:

: 13121-99-8
pyridin-4-ylacetonitrile

: 148671-44-7
3-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-5-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: trichlorophosphate / 1 h / 100 °C

2.2: 3.5 h / Reflux

With potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.05.045