2-methyl-3,5-diphenyl pyridine

Base Information

• Chemical Name: 2-methyl-3,5-diphenyl pyridine
• CAS No.: 109812-50-2
• Molecular Formula: C₁₈H₁₅N
• Molecular Weight: 245.324
• Mol file: 109812-50-2.mol

Synonyms:2-methyl-3,5-diphenyl pyridine

Chemical Property of 2-methyl-3,5-diphenyl pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-3,5-diphenyl pyridine

There total 7 articles about 2-methyl-3,5-diphenyl pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

L-alanin (56-41-7,25191-17-7,18875-37-1) + phenylacetaldehyde (122-78-1) → 2-methyl-3,5-diphenyl pyridine (109812-50-2)

Guidance literature:

With tert.-butylhydroperoxide; iodine; In N,N-dimethyl acetamide; at 20 - 70 ℃; for 1.83333h; Molecular sieve; Inert atmosphere;

DOI:10.1039/c0gc00753f

Reference yield: 63.0%

L-Aspartic acid (56-84-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) + phenylacetaldehyde (122-78-1) → 2-methyl-3,5-diphenyl pyridine (109812-50-2)

Guidance literature:

With tert.-butylhydroperoxide; iodine; In N,N-dimethyl acetamide; at 20 - 70 ℃; Molecular sieve; Inert atmosphere;

DOI:10.1039/c0gc00753f

Reference yield: 60.0%

benzonitrile (100-47-0) + phenylacetylene (536-74-3) → 2-methyl-3,5-diphenyl pyridine (109812-50-2) + 2-methyl-3,6-diphenyl pyridine (53546-08-0)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; ferrous iodide; at 20 ℃; for 48h; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201102001

upstream raw materials:

phenylacetaldehyde

acetaldehyde

ethanol

ammonia

Downstream raw materials:

3,5-diphenyl-2-trans-styryl-pyridine