1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3,8-diaza-2-oxobicyclo[3.2.1]octane

Base Information

Chemical Name:1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3,8-diaza-2-oxobicyclo[3.2.1]octane
CAS No.:335160-97-9
Molecular Formula:C₁₈H₁₈FN₅O
Molecular Weight:339.372
Hs Code.:

Synonyms:1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3,8-diaza-2-oxobicyclo[3.2.1]octane

Suppliers and Price of 1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3,8-diaza-2-oxobicyclo[3.2.1]octane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3,8-diaza-2-oxobicyclo[3.2.1]octane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3,8-diaza-2-oxobicyclo[3.2.1]octane

There total 9 articles about 1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3,8-diaza-2-oxobicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 335160-93-5
1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

: 335160-97-9
1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3,8-diaza-2-oxobicyclo[3.2.1]octane

Guidance literature:: With triethylsilane; trifluorormethanesulfonic acid; In dichloromethane; acetonitrile; for 336h;
DOI:10.1021/ol015504w

Reference yield:

: (1S,5S)-1-Benzyl-3-(2,4-dimethoxy-benzyl)-3,8-diaza-bicyclo[3.2.1]octan-2-one; hydrochloride

: 335160-97-9
1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3,8-diaza-2-oxobicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / Na(AcO)3BH; 4 Angstroem molecular sieves / 1,2-dichloro-ethane / 24 h

2: TfOH; Et₃SiH / CH₂Cl₂; acetonitrile / 336 h

With triethylsilane; trifluorormethanesulfonic acid; 4 A molecular sieve; sodium tris(acetoxy)borohydride; In dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/ol015504w

Reference yield:

: 5(S)-5-allyl-3-benzyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-2-piperazinone

: 335160-97-9
1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3,8-diaza-2-oxobicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 7 steps

1.1: OsO₄; NMO / 2-methyl-propan-2-ol; tetrahydrofuran; H₂O / 2.5 h

1.2: NaIO₄; NaHCO₃ / H₂O; 2-methyl-propan-2-ol; tetrahydrofuran / 2 h

2.1: 70 percent / NaBH₄ / ethanol / 0.33 h / 0 °C

3.1: 90 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

4.1: 63 percent / LDA / tetrahydrofuran / -78 - 0 °C

5.1: 100 percent / HCl / ethyl acetate / 0.38 h / 0 °C

6.1: 56 percent / Na(AcO)3BH; 4 Angstroem molecular sieves / 1,2-dichloro-ethane / 24 h

7.1: TfOH; Et₃SiH / CH₂Cl₂; acetonitrile / 336 h

With hydrogenchloride; triethylsilane; sodium tetrahydroborate; osmium(VIII) oxide; N-methyl-2-indolinone; trifluorormethanesulfonic acid; 4 A molecular sieve; sodium tris(acetoxy)borohydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ol015504w