(5R)-5-(5-bromo-2-fluorophenyl)-6-chloro-5-methyl-6-(trifluoromethyl)morpholin-3-one

Base Information

Chemical Name:(5R)-5-(5-bromo-2-fluorophenyl)-6-chloro-5-methyl-6-(trifluoromethyl)morpholin-3-one
CAS No.:1443035-39-9
Molecular Formula:C₁₂H₉BrClF₄NO₂
Molecular Weight:390.56
Hs Code.:

Synonyms:(5R)-5-(5-bromo-2-fluorophenyl)-6-chloro-5-methyl-6-(trifluoromethyl)morpholin-3-one

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Chemical Property of (5R)-5-(5-bromo-2-fluorophenyl)-6-chloro-5-methyl-6-(trifluoromethyl)morpholin-3-one

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Technology Process of (5R)-5-(5-bromo-2-fluorophenyl)-6-chloro-5-methyl-6-(trifluoromethyl)morpholin-3-one

There total 8 articles about (5R)-5-(5-bromo-2-fluorophenyl)-6-chloro-5-methyl-6-(trifluoromethyl)morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1443035-37-7
C₁₂H₁₀BrF₄NO₃

: 1443035-39-9
(5R)-5-(5-bromo-2-fluorophenyl)-6-chloro-5-methyl-6-(trifluoromethyl)morpholin-3-one

Guidance literature:: C₁₂H₁₀BrF₄NO₃; With thionyl chloride; In dichloromethane; at 0 ℃; for 0.5h;

With pyridine; In dichloromethane; for 0.5h;

Reference yield:

: 1266784-23-9
(RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid

: 1443035-39-9
(5R)-5-(5-bromo-2-fluorophenyl)-6-chloro-5-methyl-6-(trifluoromethyl)morpholin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 48 h / Reflux

2.1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

3.1: sodium hydroxide / water; 1,4-dioxane / pH 10 - 11 / Cooling

4.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 80 °C

5.1: tetrabutylammonium triphenyldifluorosilicate / tetrahydrofuran / 0.33 h / 20 °C

6.1: thionyl chloride / dichloromethane / 0.5 h / 0 °C

6.2: 0.5 h

With thionyl chloride; sulfuric acid; sodium hydrogencarbonate; tetrabutylammonium triphenyldifluorosilicate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1350523-51-1
rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionitrile

: 1443035-39-9
(5R)-5-(5-bromo-2-fluorophenyl)-6-chloro-5-methyl-6-(trifluoromethyl)morpholin-3-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; acetic acid / water / 16 h / Reflux

2.1: sulfuric acid / 48 h / Reflux

3.1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

4.1: sodium hydroxide / water; 1,4-dioxane / pH 10 - 11 / Cooling

5.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 80 °C

6.1: tetrabutylammonium triphenyldifluorosilicate / tetrahydrofuran / 0.33 h / 20 °C

7.1: thionyl chloride / dichloromethane / 0.5 h / 0 °C

7.2: 0.5 h

With hydrogenchloride; thionyl chloride; sulfuric acid; sodium hydrogencarbonate; acetic acid; tetrabutylammonium triphenyldifluorosilicate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;