(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methylmorpholin-3-one

Base Information

Chemical Name:(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methylmorpholin-3-one
CAS No.:1443035-41-3
Molecular Formula:C₁₂H₉BrF₃NO₂
Molecular Weight:336.108
Hs Code.:

Synonyms:(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methylmorpholin-3-one

Suppliers and Price of (5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methylmorpholin-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methylmorpholin-3-one

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Technology Process of (5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methylmorpholin-3-one

There total 9 articles about (5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methylmorpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1443035-39-9
(5R)-5-(5-bromo-2-fluorophenyl)-6-chloro-5-methyl-6-(trifluoromethyl)morpholin-3-one

: 1443035-41-3
(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methylmorpholin-3-one

Guidance literature:: With zinc-copper couple; acetic acid; at 20 ℃; for 16h;

Reference yield:

: 1350523-51-1
rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionitrile

: 1443035-41-3
(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methylmorpholin-3-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; acetic acid / water / 16 h / Reflux

2.1: sulfuric acid / 48 h / Reflux

3.1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

4.1: sodium hydroxide / water; 1,4-dioxane / pH 10 - 11 / Cooling

5.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 80 °C

6.1: tetrabutylammonium triphenyldifluorosilicate / tetrahydrofuran / 0.33 h / 20 °C

7.1: thionyl chloride / dichloromethane / 0.5 h / 0 °C

7.2: 0.5 h

8.1: acetic acid; zinc-copper couple / 16 h / 20 °C

With hydrogenchloride; thionyl chloride; sulfuric acid; zinc-copper couple; sodium hydrogencarbonate; acetic acid; tetrabutylammonium triphenyldifluorosilicate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1266784-23-9
(RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid

: 1443035-41-3
(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methylmorpholin-3-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 48 h / Reflux

2.1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

3.1: sodium hydroxide / water; 1,4-dioxane / pH 10 - 11 / Cooling

4.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 80 °C

5.1: tetrabutylammonium triphenyldifluorosilicate / tetrahydrofuran / 0.33 h / 20 °C

6.1: thionyl chloride / dichloromethane / 0.5 h / 0 °C

6.2: 0.5 h

7.1: acetic acid; zinc-copper couple / 16 h / 20 °C

With thionyl chloride; sulfuric acid; zinc-copper couple; sodium hydrogencarbonate; acetic acid; tetrabutylammonium triphenyldifluorosilicate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;