1266784-23-9

Usage

Uses

Used in Pharmaceutical Industry:
(RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid is used as an intermediate in the synthesis of various pharmaceutical compounds due to its unique molecular structure and the potential for different biological activities based on its stereochemistry.
Used in Chemical Research:
(RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid serves as a valuable research tool for studying the effects of stereochemistry on biological activity, as well as for exploring its potential applications in the development of new drugs and therapies.
Used in Material Science:
The unique properties of (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid, such as the presence of bromine and fluorine atoms, may also make it useful in the development of new materials with specific characteristics for various industrial applications.

Upstream product

• 1350523-51-1 rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionitrile 
• 1374765-83-9 2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid hydrochloride 
• 1266784-17-1 (RS)-5-(5-bromo-2-fluorophenyl)-5-methyl-imidazolidine-2,4-dione 
• 910912-20-8 5-bromo-2-fluoro-N-methoxy-N-methylbenzamide 
• 198477-89-3 1-(5-bromo-2-fluorophenyl)ethan-1-one 
• 146328-85-0 5-bromo-2-fluoro-benzoic acid 

Downstream Products

• 1266784-18-2 rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid methyl ester 
• 1266784-13-7 rac-5-(5-bromo-2-fluorophenyl)-5-methylmorpholin-3-one 
• 1266784-24-0 (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propan-1-ol 
• 1266784-29-5 rac-N-(2-(5-bromo-2-fluorophenyl)-1-hydroxypropan-2-yl)-2-chloroacetamide 
• 1266784-31-9 (RS)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one 
• 1266784-38-6 (R)-(+)-N-[1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide 
• 1266784-40-0 (S)-(-)-N-[1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide 
• 1266785-76-5 N-[(RS)-1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-3-phenyl-acrylamide 
• 1313525-71-1 2-(5-bromo-2-fluorophenyl)-2-(2-chloroacetylamino)propionic acid methyl ester 
• 1313525-72-2 3-(5-bromo-2-fluorophenyl)-1,3-dimethylpiperazine-2,5-dione 
• 1313525-73-3 3-(5-bromo-2-fluorophenyl)-1,3-dimethyl-5-thioxopiperazin-2-one 
• 1313525-74-4 5-amino-3-(5-bromo-2-fluorophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one 
• 1313525-75-5 [6-(5-bromo-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester 
• 1313525-76-6 [6-(5-amino-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads

1,4-Oxazines are presented, which show good in vitro inhibition in enzymatic and cellular BACE1 assays. We describe lead optimization focused on reducing the amidine pKa while optimizing interactions in the BACE1 active site. Our strategy permi

5-ARYL-1-IMINO-1-OXO-[1,2,4]THIADIAZINES

The present invention provides a compound of formula I' having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are

5-(3-AMINOPHENYL)-5-ALKYL-5,6-DIHYDRO-2H-[1,4]OXAZIN-3-AMINE DERIVATIVES

The present invention relates to novel 5-(3-aminophenyl)-5-alkyl-5,6-dihydro-2H-[1,4]oxazin-3-amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also direct

3-AMINO-5,6-DIHYDRO-1H-PYRAZIN-2-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER FORMS OF DEMENTIA

The present invention relates to novel 3-amino-5,6-dihydro-1H-pyrazin-2-one derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical com

5-(3-AMINOPHENYL)-5-ALKYL-5,6-DIHYDRO-2H-[1,4]OXAZIN-3-AMINE DERIVATIVES

The present invention relates to novel 5-(3-aminophenyl)-5-alkyl-5,6-dihydro- 2H-[1,4]oxazin-3-amine derivatives as inhibitors of beta-secretase, also known as beta- site amyloid cleaving enzyme, BACE, BACE 1, Asp2, or memapsin2. The invention is also dir

6-DIFLUOROMETHYL-5,6-DIHYDRO-2H-[1,4]OXAZIN-3-AMINE DERIVATIVES

The invention relates to novel 6-difluoromethyl-5,6-dihydro-2H-[l,4]oxazin-3- amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceut

5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS

The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

3-AMINO-5,6-DIHYDRO-1H-PYRAZIN-2-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ALZHEIMER?S DISEASE AND OTHER FORMS OF DEMENTIA

The present invention relates to novel 3-amino-5,6-dihydro-1H-pyrazin-2-one derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical com

1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS

The present invention relates to 1,4 Oxazines of formula (I): having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the pre

PYRAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS

The invention relates to novel heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.